Projects per year
Personal profile
Personal profile
Dr. Kumaraswami received his Ph.D. in microbiology and immunology from the University of Tennessee Health Sciences Center in Memphis. He then completed a postdoctoral fellowship at The University of Texas M.D. Anderson Cancer Center in Houston, Texas. In 2008, Dr. Kumaraswami received the Amgen Award for Basic Science Research from the M.D. Anderson Alumni and Faculty Association. He joined the Center for Molecular and Translational Human Infectious Diseases Research at The Methodist Hospital Research Institute in 2010.
Research interests
Dr. Kumaraswami conducts translational research on the gene regulatory and drug-binding mechanisms of transcription regulators in bacterial pathogens such as Staphylococcus aureus. His research focuses on three major proteins (RopB, RofA, and RocA) that are involved in the coordinated regulation of virulence gene expression and group A streptococci pathogenesis.
Education/Academic qualification
Veterinary Sciences, BVSc, Tamilnadu Veterinary and Animal Sciences, Chennai
Microbial Genetics and Structural Biology, PhD, University of Tennessee Health Science Center
Structural Biology, Postdoctoral Fellowship, University of Texas MD Anderson Cancer Center
Research Area Keywords
- Infectious Disease & Pathology
Free-text keywords
- GAS pathogenesis
- Staphylococcus Aureus
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Collaborations and top research areas from the last five years
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Molecular Mechanism of Virulence Regulation in Streptococcus Pyogenes
Kumaraswami, M. (PI) & Olsen, R. J. (Key Personnel)
6/7/21 → 5/31/26
Project: Federal Funding Agencies
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Molecular mechanism of streptococcal adaptation to host nutritional defenses
Kumaraswami, M. (PI) & Olsen, R. J. (Key Personnel)
2/25/20 → 1/31/26
Project: Federal Funding Agencies
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The role of the gut microbiome in the neuropathology of traumatic brain injury
Villapol, S. (PI) & Kumaraswami, M. (Key Personnel)
10/1/18 → 3/31/22
Project: Federal Funding Agencies
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Molecular mechanism of virulence regulation in Streptococcus pyogenes
Kumaraswami, M. (PI) & Olsen, R. J. (Key Personnel)
3/1/15 → 2/28/21
Project: Federal Funding Agencies
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Mechanism of streptococcus virulence regulation by bacterial peptide signals
Kumaraswami, M. (PI) & Olsen, R. J. (CoI)
Natl Inst of AllergyandInfectious Disease
8/15/13 → 7/31/15
Project: Federal Funding Agencies
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Engineered probiotic overcomes pathogen defences using signal interference and antibiotic production to treat infection in mice
Do, H., Li, Z. R., Tripathi, P. K., Mitra, S., Guerra, S., Dash, A., Weerasekera, D., Makthal, N., Shams, S., Aggarwal, S., Singh, B. B., Gu, D., Du, Y., Olsen, R. J., LaRock, C., Zhang, W. & Kumaraswami, M., Feb 2024, In: Nature Microbiology. 9, 2, p. 502-513 12 p., 9.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Manganese uptake by MtsABC contributes to the pathogenesis of human pathogen group A streptococcus by resisting host nutritional immune defenses
Makthal, N., Saha, S., Huang, E., John, J., Meena, H., Aggarwal, S., Högbom, M. & Kumaraswami, M., Jul 2024, In: Infection and Immunity. 92, 7, p. e0007724Research output: Contribution to journal › Article › peer-review
Open Access -
The leaderless communication peptide (LCP) class of quorum-sensing peptides is broadly distributed among Firmicutes
Aggarwal, S., Huang, E., Do, H., Makthal, N., Li, Y., Bapteste, E., Lopez, P., Bernard, C. & Kumaraswami, M., Sep 23 2023, In: Nature Communications. 14, 1, p. 5947 5947.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Managing Manganese: The Role of Manganese Homeostasis in Streptococcal Pathogenesis
Aggarwal, S. & Kumaraswami, M., Jun 21 2022, In: Frontiers in Cell and Developmental Biology. 10, p. 921920 921920.Research output: Contribution to journal › Review article › peer-review
Open Access7 Scopus citations -
Pvr and distinct downstream signaling factors are required for hemocyte spreading and epidermal wound closure at Drosophila larval wound sites
Tsai, C. R., Wang, Y., Jacobson, A., Sankoorikkal, N., Chirinos, J. D., Burra, S., Makthal, N., Kumaraswami, M. & Galko, M. J., Jan 2022, In: G3: Genes, Genomes, Genetics. 12, 1, jkab388.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations