Dr. Zage graduated from The Johns Hopkins University in 1990 with a B.A. degree in biology and subsequently received his M.D. and Ph.D. degrees from Columbia University in New York. He completed a residency in pediatrics at the University of Chicago Children's Hospital, followed by a fellowship in pediatric hematology/oncology at the Children's Memorial Hospital in Chicago. During his fellowship, he developed an interest in the pathogenesis of pediatric solid tumors, particularly neuroblastoma and retinoblastoma. He was an Assistant Professor in the Division of Pediatrics at M. D. Anderson Cancer Center from 2006 to 2011, where he also served as a research co-director of the Retinoblastoma Center of Houston. He became a member of The Methodist Hospital Research Institute in 2008. In 2011, Dr. Zage accepted a position as an Assistant Professor at Baylor College of Medicine and as a member of the solid tumor and developmental therapeutics teams at Texas Children's Hospital.

Dr. Zage continues to serve as a co-director of the Retinoblastoma Center of Houston and is an adjunct member of the Neuroscience program at the University of Texas Graduate School of Biomedical Sciences. He was awarded the Young Investigator Award from the American Society of Pediatric Hematology/Oncology in 2009 for his research focused on novel therapies for children with solid tumors in general and neuroblastoma in particular.

Dr. Zage's laboratory is primarily interested in evaluating the efficacy of novel therapies for children with neuroblastoma, retinoblastoma and other childhood solid tumors and in understanding the critical genetic and molecular events that could be used as targets for new treatments. He is developing a comprehensive program for the treatment of children with recurrent or refractory neuroblastoma, including chemotherapy, novel biologically targeted agents and immunotherapy. he collaborates with other institutions in the development of innovative approaches to treatments for all children with cancer.