Projects per year
Personal profile
Personal profile
Dr. Mitra had a brilliant academic career at Calcutta University, India from which he received MS in Biochemitry in 1959. After earning a PhD from the University of Wisconsin in 1964, Dr. Mitra did postdoctoral research in Arthur Kornberg’s laboratory at Stanford Medical School. He then returned to India to join Bose Institute, Calcutta, as an assistant professor in 1966, and became an associate professor in 1971. He came back to the U.S. in 1971 to join the Biology Division of Oak Ridge National Laboratory as a senior research investigator and subsequently became leader of the Nucleic Acid Enzymology Group. He also served as an adjunct professor of the University of Tennessee Graduate School of Biomedical Sciences. Dr. Mitra moved to the newly created Sealy Center for Molecular Science at the University of Texas Medical Branch (UTMB), Galveston, TX in 1992 as professor of Biochemistry & Molecular Biology, and later as senior scientist in the Sealy Center for Molecular Medicine. After his retirement from UTMB in 2013, he joined Houston Methodist Research Institute as a full member in Radiation Oncology.
He was elected a fellow of AAAS in 1989 and as a fellow of the Japan Society for Promotion of Science, participating in lecture tours in Japan in 1991, 1999, and 2008. He was awarded Mark Brothers of Indiana Prize in 2009. Dr. Mitra has been continuously funded by NIH since 1982 and has been serving on various NIH and other review panels.
Research interests
Working in the broad area of genome damage, its repair, and its influence in carcinogenesis and cancer therapy, Dr. Mitra has made several seminal discoveries during his tenure at Oak Ridge National Laboratory, including the characterization of the E. coli repair protein for the mutagenic DNA base O-6 methylguanine produced by mutagens and anticancer alkylating agents, the naming of the repair protein MGMT, and the cloning of human MGMT. More recently, Dr. Mitra’s group characterized a new family of DNA repair proteins that they named NEILs for oxidative genome damage. The recent research focus of Dr. Mitra’s group is enhancement of chemo/radiation sensitivity of tumor cells using targeted DNA repair inhibitors. After the early studies on MGMT inhibition, his current research aims to identify inhibitors for repair pathways for oxidative/radiation damage.
Education/Academic qualification
Biochemistry/Neurochemistry , Research Doctorate, Physicochemical studies of RNA genomes in viruses, Department of Biochemistry University of Wisconsin Madison 6
Sep 2 1960 → Jan 15 1964
Award Date: Jun 5 1964
Biochemistry, MS, Lecithinase in Vibrio el tor, University of Calcutta
Aug 5 1957 → Mar 10 1959
Award Date: Jun 14 1959
Biochemistry, Postdoctoral Fellowship, Enmzymatice mechanism of DNA Replication, Stanford University
Jan 24 1964 → Dec 19 1965
Research Fellowship, Department of Biochemistry, University of Calcutta
University Fellow, Department of Biochemistry, University of Wisconsin, Madison,WI
Biochemistry, PhD, University of Wisconsin-Madison
External positions
Adjunct Prof of Cell Mol Biol, Texas A&M University
Sep 1 2015 → Aug 31 2016
Adjunct Professor of Biochemistry & M ol Biol., UTMB
Sep 1 2013 → Aug 31 2016
Research Area Keywords
- Neurosciences
Free-text keywords
- Genome damage
- Repair
- Cancer mechanisms
- Cancer therapy
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Collaborations and top research areas from the last five years
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Influence of pre-analytical factors in glioblastoma MGMT promoter methylation biomarker assay
Rostomily, R. C. (PI), Mitra, S. (Key Personnel) & Powell, S.Z.-E. (Key Personnel)
6/1/20 → 5/31/25
Project: Federal Funding Agencies
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Structural Cell Biology of DNA Repair Machines.
Mitra, S. (PI)
9/13/16 → 8/31/21
Project: Federal Funding Agencies
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Tumor vasculature-targeted nanotherapeutics for DNA damage response
Jenkins, N. A. (Key Personnel), Liu, X. (Key Personnel) & Mitra, S. (Key Personnel)
12/1/15 → 5/31/22
Project: Federal Funding Agencies
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Novel role of TDP-43 in DNA strand break repair and implications to ALS
Hegde, M. (PI) & Mitra, S. (Key Personnel)
Muscular Dystrophy Association
5/1/14 → 10/31/17
Project: Non Profit
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The Repair of Oxidative Genome Damage Associated with Gene Activation
Mitra, S. (PI)
Natl Inst of General Medical Sciences
4/15/14 → 1/31/19
Project: Federal Funding Agencies
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FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease
Kodavati, M., Wang, H., Guo, W., Mitra, J., Hegde, P. M., Provasek, V., Rao, V. H. M., Vedula, I., Zhang, A., Mitra, S., Tomkinson, A. E., Hamilton, D. J., Van Den Bosch, L. & Hegde, M. L., Mar 9 2024, In: Nature Communications. 15, 1, 2156.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Characterizing the Repair of DNA Double-Strand Breaks: A Review of Surrogate Plasmid-Based Reporter Methods
Dutta, A., Mitra, J., Hegde, P. M., Mitra, S. & Hegde, M. L., 2023, In: Methods in molecular biology (Clifton, N.J.). 2701, p. 173-182 10 p.Research output: Contribution to journal › Review article › peer-review
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SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
Mitra, J., Kodavati, M., Provasek, V. E., Rao, K. S., Mitra, S., Hamilton, D. J., Horner, P. J., Vahidy, F. S., Britz, G. W., Kent, T. A. & Hegde, M. L., Sep 2022, In: Ageing Research Reviews. 80, 101687.Research output: Contribution to journal › Review article › peer-review
Open Access11 Scopus citations -
Combinatorial effect of plk1 inhibition with temozolomide and radiation in glioblastoma
Pandey, A., Tripathi, S. C., Mai, J., Hanash, S. M., Shen, H., Mitra, S. & Rostomily, R. C., Oct 12 2021, In: Cancers. 13, 20, 5114.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin
Bacolla, A., Sengupta, S., Ye, Z., Yang, C., Mitra, J., De-Paula, R. B., Hegde, M. L., Ahmed, Z., Mort, M., Cooper, D. N., Mitra, S. & Tainer, J. A., Jan 11 2021, In: Nucleic Acids Research. 49, 1, p. 221-243 23 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations
Prizes
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Fellow, American Association for the Advancement of Science
Mitra, S. (Recipient), 1982
Prize: Fellowship awarded competitively
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Fellow of Association for Biotechnology and Pharmacy (ABAP), India
Mitra, S. (Recipient), 2015
Prize: National/international honor
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Lifetime Achievement Award for American Association of Cancer Research of Indian America Scientists
Mitra, S. (Recipient), 2016
Prize: Prize (including medals and awards)