Projects per year
Personal profile
Personal profile
Dr. Little is a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center and program director of the Cardiovascular Fellowship. In addition, he is director of Structural Heart for the Houston Methodist Hospital System, and medical director of the Valve Clinic. He also serves as director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).
After completing sub-specialty Cardiology training at the Royal College of Physicians and Surgeon of Canada, Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston. In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of Houston Methodist DeBakey Heart & Vascular Center.
He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. For the American Society of Echocardiography, Dr. Little served on the Board of Directors, was chair of the guidelines committee, and is currently serving as President, American Society of Echocardiography
Dr. Little has given more than 150 invited lectures nationally and internationally. He is a Professor of Medicine at Weill Cornell Medical College and Adjunct Professor at Rice University, Dept. of Bioengineering.
Research interests
Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions.
As principal investigator, Dr. Little leads Houston Methodists participation in the international Triluminate Clinical Trial of catheter-based therapy for tricuspid valve regurgitation and participates as a co-investigator in multiple other structural heart trials at Houston Methodist.
Education/Academic qualification
Echocardiography, Clinical Fellowship, Baylor College of Medicine
Jul 1 2004 → Jun 1 2005
Award Date: Jun 1 2005
Internal Medicine, Residency, Western University
Jul 1 1997 → Jun 1 2003
Award Date: Jun 1 2003
MD, McMaster University School of Medicine
Sep 1 1994 → May 1 1997
Award Date: May 1 1997
External positions
Professor of Medicine, Weill Cornell Medical College
Jun 1 2014 → …
Adjunct Associate Professor, Rice University
May 1 2014 → …
Research Area Keywords
- Heart & Vascular
- Imaging & Radiology
- Clinical Translation & Trials
- Clinical Care
Free-text keywords
- Valvular disease
- Mitral regurgitation
- Echocardiography
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Evolut EXPAND TAVR II Pivotal Trial
Kleiman, N., Chang, S., Faza, N., Goel, S., Little, S. H., Reardon, M. J. & Yousefzai, R.
6/27/23 → …
Project: Clinical Trial
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Cephea Early Feasibility Study
Goel, S., Faza, N., Kleiman, N., Little, S. H., Reardon, M. J. & Yousefzai, R.
7/28/22 → …
Project: Clinical Trial
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The JenaValve ALIGN-AR Pivotal Trial (ALIGN-AR)
Reardon, M. J., Chang, S., Faza, N., Goel, S., Kleiman, N. & Little, S. H.
9/29/21 → …
Project: Clinical Trial
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TTVR Early Feasibility Study
Goel, S., Faza, N., Kleiman, N., Lador, A., Little, S. H., Reardon, M. J., Valderrábano, M. & Yousefzai, R.
9/15/21 → …
Project: Clinical Trial
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An Early Feasibility Study of the HighLife 28mm Trans-Septal Transcatheter Mitral Valve Replacement System
Goel, S., Faza, N., Kleiman, N., Little, S. H. & Reardon, M. J.
6/29/21 → …
Project: Clinical Trial
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Characteristics and Outcomes of Patients Ineligible for Tricuspid Transcatheter Edge-to-Edge Repair
Hatab, T., Bou Chaaya, R. G., Samimi, S., Qamar, F., Faza, N., Little, S. H., Reardon, M. J., Kleiman, N., Zoghbi, W. A., Guha, A., Zaid, S. & Goel, S., Mar 2024, In: Structural Heart. 8, 2, 100235.Research output: Contribution to journal › Article › peer-review
Open Access -
Echocardiographic Profiling Predicts Clinical Outcomes After Mitral Transcatheter Edge-to-Edge Repair
Hatab, T., Samimi, S., Chaaya, R. G. B., Qamar, F., Kharsa, C., Wessly, P., Faza, N., Little, S. H., Atkins, M. D., Reardon, M. J., Kleiman, N., Zoghbi, W. A., Nagueh, S. F., Zaid, S. & Goel, S., 2024, In: Journal of the American Heart Association. 13, 5, e032784.Research output: Contribution to journal › Article › peer-review
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Feasibility and Safety of Intracardiac Echocardiography Guidance in Mitral Transcatheter Edge-to-Edge Repair: Analysis of the National Inpatient Sample Data From 2015 to 2020
Hashem, A., Khalouf, A., Agrawal, A., Mohamad, M. S., Nayfeh, T., Kashou, A., Chaaya, R. G. B., Rai, D., Verghese, B., Little, S. H., Goldsweig, A., Naidu, S. & Goel, S. S., Jan 2024, In: Current Problems in Cardiology. 49, 1 Pt A, p. 102042 102042.Research output: Contribution to journal › Review article › peer-review
1 Scopus citations -
Guidelines for the Evaluation of Prosthetic Valve Function With Cardiovascular Imaging: A Report From the American Society of Echocardiography Developed in Collaboration With the Society for Cardiovascular Magnetic Resonance and the Society of Cardiovascular Computed Tomography
Zoghbi, W. A., Jone, P. N., Chamsi-Pasha, M. A., Chen, T., Collins, K. A., Desai, M. Y., Grayburn, P., Groves, D. W., Hahn, R. T., Little, S. H., Kruse, E., Sanborn, D., Shah, S. B., Sugeng, L., Swaminathan, M., Thaden, J., Thavendiranathan, P., Tsang, W., Weir-McCall, J. R. & Gill, E., Jan 2024, In: Journal of the American Society of Echocardiography. 37, 1, p. 2-63 62 p.Research output: Contribution to journal › Review article › peer-review
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Intraprocedural Doppler and Invasive Hemodynamic Profiling Predict Clinical Outcomes After Mitral TEER
Zaid, S., Wessly, P., Hatab, T., Faza, N., Little, S. H., Atkins, M. D., Reardon, M. J., Kleiman, N., Zoghbi, W. A. & Goel, S., Apr 2024, In: JACC: Cardiovascular Imaging. 17, 4, p. 454-456 3 p.Research output: Contribution to journal › Letter › peer-review
Open Access
Prizes
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Figure of the month in JACC imaging
Vukicevic, Marija (Recipient) & Little, Stephen H. (Recipient), Feb 1 2017
Prize: Other distinction
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Siemens Healthineers Research Collaboration grant contest winners
Little, Stephen H. (Recipient) & Vukicevic, Marija (Recipient), Mar 6 2018
Prize: Other distinction