Projects per year
Personal profile
Personal profile
Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.
Research interests
Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.
Education/Academic qualification
Immunology, Postdoctoral Associate, Baylor College of Medicine
Transplantation Immunology, Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Immunology, Postdoctoral Fellowship, University of Toronto
Biomedical Science, PhD, University of Toronto
Research Area Keywords
- Transplantation
Free-text keywords
- Transplantation
- Type 1 diabetes
- T cell
- Immune tolerance
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Collaborations and top research areas from the last five years
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Impact of Irreversible T Cell Dysfunction on Transplant Outcomes
1/12/24 → 12/31/24
Project: Federal Funding Agencies
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Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.
4/10/19 → 8/31/19
Project: Federal Funding Agencies
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IRF4-dependent T-cell effector programs in governing transplant outcomes
5/1/18 → 1/11/24
Project: Federal Funding Agencies
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CD4+ T cell immunity is dependent on an intrinsic stem-like program
Zou, D., Yin, Z., Yi, S. G., Wang, G., Guo, Y., Xiao, X., Li, S., Zhang, X., Gonzalez, N. M., Minze, L. J., Wang, L., Wong, S. T. C., Osama Gaber, A., Ghobrial, R. M., Li, X. C. & Chen, W., Jan 2024, In: Nature immunology. 25, 1, p. 66-76 11 p.Research output: Contribution to journal › Article › peer-review
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Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8+ T Cell Immunity against Tumor
Yu, A., Fu, J., Yin, Z., Yan, H., Xiao, X., Zou, D., Zhang, X., Zu, X., Li, X. C. & Chen, W., Nov 2023, In: Research. 6, 0271.Research output: Contribution to journal › Article › peer-review
Open Access -
T cells: Surviving a decade of cell proliferation in vivo
Chen, W. & Li, X. C., May 2023, In: American Journal of Transplantation. 23, 5, p. 593-594 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
The Functional Adaptability of Hyporesponsive T Cells and Its Impact on Transplant Outcomes
Zou, D., Zhang, X. & Chen, W., Sep 2023, In: Current Transplantation Reports. 10, 3, p. 147-152 6 p.Research output: Contribution to journal › Review article › peer-review
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The transcription factor IRF4 determines the anti-tumor immunity of CD8+ T cells
Yan, H., Dai, Y., Zhang, X., Zhang, H., Xiao, X., Fu, J., Zou, D., Yu, A., Jiang, T., Li, X. C., Zhao, Z. & Chen, W., Nov 17 2023, In: iScience. 26, 11, 108087.Research output: Contribution to journal › Article › peer-review
Open Access