A comprehensive genetic map of the mouse genome

William F. Dietrich; Joyce Miller; Robert Steen; Mark A. Merchant; Deborah Damron-Boles; Zeeshan Husain; Robert Dredge; Mark J. Daly; Kimberly A. Ingalls; Tara J. O'Connor; Cheryl A. Evans; Margaret M. DeAngelis; David M. Levinson; Leonid Kruglyak; Nathan Goodman; Neal G. Copeland; Nancy A. Jenkins; Trevor L. Hawkins; Lincoln Stein; David C. Page; Eric S. Lander

doi:10.1038/380149a0

A comprehensive genetic map of the mouse genome

William F. Dietrich, Joyce Miller, Robert Steen, Mark A. Merchant, Deborah Damron-Boles, Zeeshan Husain, Robert Dredge, Mark J. Daly, Kimberly A. Ingalls, Tara J. O'Connor, Cheryl A. Evans, Margaret M. DeAngelis, David M. Levinson, Leonid Kruglyak, Nathan Goodman, Neal G. Copeland, Nancy A. Jenkins, Trevor L. Hawkins, Lincoln Stein, David C. PageEric S. Lander

Research output: Contribution to journal › Article › peer-review

760 Scopus citations

Abstract

The availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.

Original language	English (US)
Pages (from-to)	149-152
Number of pages	4
Journal	Nature
Volume	380
Issue number	6570
DOIs	https://doi.org/10.1038/380149a0
State	Published - Mar 14 1996

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Dietrich, W. F., Miller, J., Steen, R., Merchant, M. A., Damron-Boles, D., Husain, Z., Dredge, R., Daly, M. J., Ingalls, K. A., O'Connor, T. J., Evans, C. A., DeAngelis, M. M., Levinson, D. M., Kruglyak, L., Goodman, N., Copeland, N. G., Jenkins, N. A., Hawkins, T. L., Stein, L., ... Lander, E. S. (1996). A comprehensive genetic map of the mouse genome. Nature, 380(6570), 149-152. https://doi.org/10.1038/380149a0

Dietrich, WF, Miller, J, Steen, R, Merchant, MA, Damron-Boles, D, Husain, Z, Dredge, R, Daly, MJ, Ingalls, KA, O'Connor, TJ, Evans, CA, DeAngelis, MM, Levinson, DM, Kruglyak, L, Goodman, N, Copeland, NG , Jenkins, NA, Hawkins, TL, Stein, L, Page, DC & Lander, ES 1996, 'A comprehensive genetic map of the mouse genome', Nature, vol. 380, no. 6570, pp. 149-152. https://doi.org/10.1038/380149a0

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title = "A comprehensive genetic map of the mouse genome",

abstract = "The availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.",

author = "Dietrich, {William F.} and Joyce Miller and Robert Steen and Merchant, {Mark A.} and Deborah Damron-Boles and Zeeshan Husain and Robert Dredge and Daly, {Mark J.} and Ingalls, {Kimberly A.} and O'Connor, {Tara J.} and Evans, {Cheryl A.} and DeAngelis, {Margaret M.} and Levinson, {David M.} and Leonid Kruglyak and Nathan Goodman and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Hawkins, {Trevor L.} and Lincoln Stein and Page, {David C.} and Lander, {Eric S.}",

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AU - Steen, Robert

AU - Merchant, Mark A.

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AU - Husain, Zeeshan

AU - Dredge, Robert

AU - Daly, Mark J.

AU - Ingalls, Kimberly A.

AU - O'Connor, Tara J.

AU - Evans, Cheryl A.

AU - DeAngelis, Margaret M.

AU - Levinson, David M.

AU - Kruglyak, Leonid

AU - Goodman, Nathan

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Hawkins, Trevor L.

AU - Stein, Lincoln

AU - Page, David C.

AU - Lander, Eric S.

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AB - The availability of dense genetic linkage maps of mammalian genomes makes feasible a wide range of studies, including positional cloning of monogenic traits, genetic dissection of polygenic traits, construction of genome-wide physical maps, rapid marker-assisted construction of congenic strains, and evolutionary comparisons. We have been engaged for the past five years in a concerted effort to produce a dense genetic map of the laboratory mouse. Here we present the final report of this project. The map contains 7,377 genetic markers, consisting of 6,580 highly informative simple sequence length polymorphisms integrated with 797 restriction fragment length polymorphisms in mouse genes. The average spacing between markers is about 0.2 centimorgans or 400 kilobases.

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A comprehensive genetic map of the mouse genome

Abstract

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