A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.

Shou jiang Tang; Sunil Geevarghese; Sammy Saab; Dorothy Martinez; Andre Van Herle; William D. Wallace; Galen R. Cortina; Sarah Dry; Ronald W. Busuttil

A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.

Shou jiang Tang, Sunil Geevarghese, Sammy Saab, Dorothy Martinez, Andre Van Herle, William D. Wallace, Galen R. Cortina, Sarah Dry, Ronald W. Busuttil

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.

Original language	English (US)
Pages (from-to)	e181-185
Journal	Archives of pathology & laboratory medicine
Volume	127
Issue number	4
State	Published - Apr 2003

ASJC Scopus subject areas

Pathology and Forensic Medicine
Medical Laboratory Technology

Cite this

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title = "A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.",

abstract = "A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.",

author = "Tang, {Shou jiang} and Sunil Geevarghese and Sammy Saab and Dorothy Martinez and {Van Herle}, Andre and Wallace, {William D.} and Cortina, {Galen R.} and Sarah Dry and Busuttil, {Ronald W.}",

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AU - Tang, Shou jiang

AU - Geevarghese, Sunil

AU - Saab, Sammy

AU - Martinez, Dorothy

AU - Van Herle, Andre

AU - Wallace, William D.

AU - Cortina, Galen R.

AU - Dry, Sarah

AU - Busuttil, Ronald W.

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N2 - A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.

AB - A diagnosis of parathyroid hormone-related protein (PTH-rP)-secreting metastatic uterine epithelioid leiomyosarcoma was made in a 61-year-old woman with humoral hypercalcemia of malignancy. A primary uterine tumor had been removed 10 years previously, which had been associated with a short history of hypercalcemia. The original uterine tumor was diagnosed as a smooth muscle tumor of uncertain malignant potential. To the best of our knowledge, this is the first reported case of a PTH-rP-secreting uterine leiomyosarcoma. We demonstrate the dramatic changes in serum calcium, phosphorus, PTH, and PTH-rP levels after tumor resection. Extensive biochemical analysis and detailed immunohistochemical and ultrastructural characterization demonstrate several features of this tumor.

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A parathyroid hormone-related protein-secreting metastatic epithelioid leiomyosarcoma. A case report and review of the literature.

Abstract

ASJC Scopus subject areas

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