Age-related elemental change in bones

C. Wang; M. H. Eisa; W. Jin; H. Shen; Y. Mi; J. Gao; Y. Zhou; H. Yao; Y. Zhao

doi:10.1016/j.nimb.2008.01.015

Age-related elemental change in bones

C. Wang, M. H. Eisa, W. Jin, H. Shen, Y. Mi, J. Gao, Y. Zhou, H. Yao, Y. Zhao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague-Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5 age groups: 1, 4, 7, 11 and 25 month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder.

Original language	English (US)
Pages (from-to)	1619-1622
Number of pages	4
Journal	Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms
Volume	266
Issue number	8
DOIs	https://doi.org/10.1016/j.nimb.2008.01.015
State	Published - Apr 2008

Keywords

Age
Calcium
Osteoporosis
PIXE
Strontium
XAFS

ASJC Scopus subject areas

Nuclear and High Energy Physics
Instrumentation

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10.1016/j.nimb.2008.01.015

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title = "Age-related elemental change in bones",

abstract = "To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague-Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5 age groups: 1, 4, 7, 11 and 25 month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder.",

keywords = "Age, Calcium, Osteoporosis, PIXE, Strontium, XAFS",

author = "C. Wang and Eisa, {M. H.} and W. Jin and H. Shen and Y. Mi and J. Gao and Y. Zhou and H. Yao and Y. Zhao",

note = "Funding Information: This work was supported by the Chinese National Science Foundation under the Grant (Nos. 10175015 and 10490180) and Shanghai leading academic discipline project B107. Prof Y. Zhang is gratefully acknowledged for giving us bone standard reference materials.",

year = "2008",

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doi = "10.1016/j.nimb.2008.01.015",

language = "English (US)",

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AU - Wang, C.

AU - Eisa, M. H.

AU - Jin, W.

AU - Shen, H.

AU - Mi, Y.

AU - Gao, J.

AU - Zhou, Y.

AU - Yao, H.

AU - Zhao, Y.

N1 - Funding Information: This work was supported by the Chinese National Science Foundation under the Grant (Nos. 10175015 and 10490180) and Shanghai leading academic discipline project B107. Prof Y. Zhang is gratefully acknowledged for giving us bone standard reference materials.

PY - 2008/4

Y1 - 2008/4

N2 - To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague-Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5 age groups: 1, 4, 7, 11 and 25 month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder.

AB - To investigate age dependence of the bone element contents and structure, lumbar and femur from Sprague-Dawley (SD) rats were chosen for their more susceptibility to fracture. These rats were divided into to 5 age groups: 1, 4, 7, 11 and 25 month-age, corresponding human beings from the young to the old. The elements contents were detected by external Proton Induced X-ray emission (PIXE) technique. X-ray Absorption Fine Structure (XAFS) method was also applied to obtain information about calcium (Ca) and phosphor (P) structure. It was found that Ca content, Ca/P ratio, valance state of Ca and P and their coordinate structure remains unaltered with age variance, whereas the content of strontium (Sr) was significantly decreasing. Sr concentration may provide a new parameter for diagnosis of bone disorder.

KW - Age

KW - Calcium

KW - Osteoporosis

KW - PIXE

KW - Strontium

KW - XAFS

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IS - 8

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Age-related elemental change in bones

Abstract

Keywords

ASJC Scopus subject areas

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