TY - JOUR
T1 - Alterations to the gut microbiome after sport-related concussion in a collegiate football players cohort
T2 - A pilot study
AU - Soriano, Sirena
AU - Curry, Kristen
AU - Sadrameli, Saeed S.
AU - Wang, Qi
AU - Nute, Michael
AU - Reeves, Elizabeth
AU - Kabir, Rasadul
AU - Wiese, Jonathan
AU - Criswell, Amber
AU - Schodrof, Sarah
AU - Britz, Gavin W.
AU - Gadhia, Rajan
AU - Podell, Kenneth
AU - Treangen, Todd
AU - Villapol, Sonia
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/5
Y1 - 2022/5
N2 - Concussions, both single and repetitive, cause brain and body alterations in athletes during contact sports. The role of the brain-gut connection and changes in the microbiota have not been well established after sports-related concussions or repetitive subconcussive impacts. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples at three time points throughout the athletic season: mid-season, following the last competitive game (post-season), and after a resting period in the off-season. Additional samples were collected from four athletes that suffered from a concussion. 16S rRNA sequencing of the gut microbiome revealed a decrease in abundance for two bacterial species, Eubacterium rectale, and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during the competitive season. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among the group of athletes that did not suffer a diagnosed concussion during the sports season. These findings provide initial evidence that detecting changes in the gut microbiome may help to improve concussion diagnosis following head injury.
AB - Concussions, both single and repetitive, cause brain and body alterations in athletes during contact sports. The role of the brain-gut connection and changes in the microbiota have not been well established after sports-related concussions or repetitive subconcussive impacts. We recruited 33 Division I Collegiate football players and collected blood, stool, and saliva samples at three time points throughout the athletic season: mid-season, following the last competitive game (post-season), and after a resting period in the off-season. Additional samples were collected from four athletes that suffered from a concussion. 16S rRNA sequencing of the gut microbiome revealed a decrease in abundance for two bacterial species, Eubacterium rectale, and Anaerostipes hadrus, after a diagnosed concussion. No significant differences were found regarding the salivary microbiome. Serum biomarker analysis shows an increase in GFAP blood levels in athletes during the competitive season. Additionally, S100β and SAA blood levels were positively correlated with the abundance of Eubacterium rectale species among the group of athletes that did not suffer a diagnosed concussion during the sports season. These findings provide initial evidence that detecting changes in the gut microbiome may help to improve concussion diagnosis following head injury.
KW - Biomarkers
KW - Brain-gut axis
KW - Microbiota
KW - Mild traumatic brain injury
KW - Neuroinflammation
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UR - http://www.scopus.com/inward/citedby.url?scp=85128296734&partnerID=8YFLogxK
U2 - 10.1016/j.bbih.2022.100438
DO - 10.1016/j.bbih.2022.100438
M3 - Article
C2 - 35284846
AN - SCOPUS:85128296734
SN - 2666-3546
VL - 21
JO - Brain, behavior, & immunity - health
JF - Brain, behavior, & immunity - health
M1 - 100438
ER -