Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor

Jing Liu; Xiaopeng Zheng; Liang Yan; Liangjun Zhou; Gan Tian; Wenyan Yin; Liming Wang; Ying Liu; Zhongbo Hu; Zhanjun Gu; Chunying Chen; Yuliang Zhao

doi:10.1021/nn506137n

Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor

Jing Liu, Xiaopeng Zheng, Liang Yan, Liangjun Zhou, Gan Tian, Wenyan Yin, Liming Wang, Ying Liu, Zhongbo Hu, Zhanjun Gu, Chunying Chen, Yuliang Zhao

Research output: Contribution to journal › Article › peer-review

505 Scopus citations

Abstract

Here, we present a precision cancer nanomedicine based on Bi₂S₃ nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi₂S₃ NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi₂S₃ NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.

Original language	English (US)
Pages (from-to)	696-707
Number of pages	12
Journal	ACS Nano
Volume	9
Issue number	1
DOIs	https://doi.org/10.1021/nn506137n
State	Published - Jan 27 2015

Keywords

BiS nanorods
X-ray computed tomography
multispectral optoacoustic tomography
photothermal therapy
thin bandgap semiconductor

ASJC Scopus subject areas

General Materials Science
General Engineering
General Physics and Astronomy

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10.1021/nn506137n

Cite this

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title = "Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor",

abstract = "Here, we present a precision cancer nanomedicine based on Bi2S3 nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi2S3 NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as {"}satellite{"} and {"}precision targeted weapon{"} for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi2S3 NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.",

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author = "Jing Liu and Xiaopeng Zheng and Liang Yan and Liangjun Zhou and Gan Tian and Wenyan Yin and Liming Wang and Ying Liu and Zhongbo Hu and Zhanjun Gu and Chunying Chen and Yuliang Zhao",

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doi = "10.1021/nn506137n",

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AU - Liu, Jing

AU - Zheng, Xiaopeng

AU - Yan, Liang

AU - Zhou, Liangjun

AU - Tian, Gan

AU - Yin, Wenyan

AU - Wang, Liming

AU - Liu, Ying

AU - Hu, Zhongbo

AU - Gu, Zhanjun

AU - Chen, Chunying

AU - Zhao, Yuliang

PY - 2015/1/27

Y1 - 2015/1/27

N2 - Here, we present a precision cancer nanomedicine based on Bi2S3 nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi2S3 NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi2S3 NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.

AB - Here, we present a precision cancer nanomedicine based on Bi2S3 nanorods (NRs) designed specifically for multispectral optoacoustic tomography (MSOT)/X-ray computed tomography (CT)-guided photothermal therapy (PTT). The as-prepared Bi2S3 NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging. These features make them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo, realizing effective tumor destruction and metastasis inhibition after intravenous injection. In addition, toxicity screening confirms that Bi2S3 NRs have well biocompatibility. This triple-modality-nanoparticle approach enables simultaneously precise cancer therapy and therapeutic monitoring.

KW - BiS nanorods

KW - X-ray computed tomography

KW - multispectral optoacoustic tomography

KW - photothermal therapy

KW - thin bandgap semiconductor

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JF - ACS Nano

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Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor

Abstract

Keywords

ASJC Scopus subject areas

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