TY - JOUR
T1 - Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 A Systematic Analysis for the Global Burden of Disease Study 2019
AU - Global Burden of Disease 2019 Cancer Collaboration
AU - Kocarnik, Jonathan M.
AU - Compton, Kelly
AU - Dean, Frances E.
AU - Fu, Weijia
AU - Gaw, Brian L.
AU - Harvey, James D.
AU - Henrikson, Hannah Jacqueline
AU - Lu, Dan
AU - Pennini, Alyssa
AU - Xu, Rixing
AU - Ababneh, Emad
AU - Abbasi-Kangevari, Mohsen
AU - Abbastabar, Hedayat
AU - Abd-Elsalam, Sherief M.
AU - Abdoli, Amir
AU - Abedi, Aidin
AU - Abidi, Hassan
AU - Abolhassani, Hassan
AU - Adedeji, Isaac Akinkunmi
AU - Adnani, Qorinah Estiningtyas Sakilah
AU - Advani, Shailesh M.
AU - Afzal, Muhammad Sohail
AU - Aghaali, Mohammad
AU - Ahinkorah, Bright Opoku
AU - Ahmad, Sajjad
AU - Ahmad, Tauseef
AU - Ahmadi, Ali
AU - Ahmadi, Sepideh
AU - Ahmed Rashid, Tarik
AU - Ahmed Salih, Yusra
AU - Akalu, Gizachew Taddesse
AU - Aklilu, Addis
AU - Akram, Tayyaba
AU - Akunna, Chisom Joyqueenet
AU - Al Hamad, Hanadi
AU - Alahdab, Fares
AU - Al-Aly, Ziyad
AU - Ali, Saqib
AU - Alimohamadi, Yousef
AU - Alipour, Vahid
AU - Aljunid, Syed Mohamed
AU - Alkhayyat, Motasem
AU - Almasi-Hashiani, Amir
AU - Almasri, Nihad A.
AU - Al-Maweri, Sadeq Ali Ali
AU - Almustanyir, Sami
AU - Alonso, Nivaldo
AU - Alvis-Guzman, Nelson
AU - Amu, Hubert
AU - Anbesu, Etsay Woldu
N1 - Publisher Copyright:
© 2022 American Medical Association. All rights reserved.
PY - 2022
Y1 - 2022
N2 - IMPORTANCE The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
AB - IMPORTANCE The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
KW - Disability-Adjusted Life Years
KW - Global Burden of Disease
KW - Global Health
KW - Humans
KW - Incidence
KW - Neoplasms/epidemiology
KW - Prevalence
KW - Quality-Adjusted Life Years
KW - Risk Factors
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U2 - 10.1001/jamaoncol.2021.6987
DO - 10.1001/jamaoncol.2021.6987
M3 - Article
C2 - 34967848
AN - SCOPUS:85122535890
SN - 2374-2437
VL - 8
SP - 420
EP - 444
JO - JAMA oncology
JF - JAMA oncology
IS - 3
ER -