TY - JOUR
T1 - Cardiovascular effects of exercise
T2 - Role of endothelial shear stress
AU - Niebauer, Josef
AU - Cooke, John P.
N1 - Funding Information:
From the Section of Vascular Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, California. This work was supported in part by Grant HL48638 from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland and a Grant-in-Aid from the American Heart Association, Dallas, Texas. Dr. Niebauer is a recipient of a stipend award (Ni 456/1–1) from the Deutsche Forschungsgemeinschaft, Bonn, Germany. Dr. Cooke is a recipient of Vascular Academic Award K07HC02660 from the National Heart, Lung, and Blood Institute and is an Established Investigator of the American Heart Association.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997/12
Y1 - 1997/12
N2 - Experimental, epidemiologic and clinical studies have provided strong evidence that physical exercise has beneficial effects on multiple physiological variables affecting cardiovascular health (lipoprotein levels, rest blood pressure and heart rate, carbohydrate tolerance, neurohormonal activity). Regular exercise has been shown to slow the progression of cardiovascular disease and to reduce cardiovascular morbidity and mortality. More recently, exercise-induced increases in blood flow and shear stress have been observed to enhance vascular function and structure. By increasing the release of nitric oxide and prostacyclin, shear stress augments endothelium-dependent vasodilation and inhibits multiple processes involved in atherogenesis and restenosis. In this review we discuss the underlying mechanisms by which exercise-induced blood flow and shear stress exert their salutary effects on cardiovascular remodeling.
AB - Experimental, epidemiologic and clinical studies have provided strong evidence that physical exercise has beneficial effects on multiple physiological variables affecting cardiovascular health (lipoprotein levels, rest blood pressure and heart rate, carbohydrate tolerance, neurohormonal activity). Regular exercise has been shown to slow the progression of cardiovascular disease and to reduce cardiovascular morbidity and mortality. More recently, exercise-induced increases in blood flow and shear stress have been observed to enhance vascular function and structure. By increasing the release of nitric oxide and prostacyclin, shear stress augments endothelium-dependent vasodilation and inhibits multiple processes involved in atherogenesis and restenosis. In this review we discuss the underlying mechanisms by which exercise-induced blood flow and shear stress exert their salutary effects on cardiovascular remodeling.
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U2 - 10.1016/S0735-1097(96)00393-2
DO - 10.1016/S0735-1097(96)00393-2
M3 - Article
C2 - 8962548
AN - SCOPUS:0030462545
SN - 0735-1097
VL - 28
SP - 1652
EP - 1660
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
IS - 7
ER -