TY - JOUR
T1 - Cartilage oligomeric matrix protein and its binding partners in the cartilage extracellular matrix
T2 - Interaction, regulation and role in chondrogenesis
AU - Acharya, Chitrangada
AU - Yik, Jasper H.N.
AU - Kishore, Ashleen
AU - Van Dinh, Victoria
AU - Di Cesare, Paul E.
AU - Haudenschild, Dominik R.
N1 - Publisher Copyright:
© 2014 International Society of Matrix Biology.
PY - 2014/7/1
Y1 - 2014/7/1
N2 - Thrombospondins (TSPs) are widely known as a family of five calcium-binding matricellular proteins. While these proteins belong to the same family, they are encoded by different genes, regulate different cellular functions and are localized to specific regions of the body. TSP-5 or Cartilage Oligomeric Matrix Protein (COMP) is the only TSP that has been associated with skeletal disorders in humans, including pseudo. achondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). The pentameric structure of COMP, the evidence that it interacts with multiple cellular proteins, and the recent reports of COMP acting as a 'lattice' to present growth factors to cells, inspired this review of COMP and its interacting partners. In our review, we have compiled the interactions of COMP with other proteins in the cartilage extracellular matrix and summarized their importance in maintaining the structural integrity of cartilage as well as in regulating cellular functions.
AB - Thrombospondins (TSPs) are widely known as a family of five calcium-binding matricellular proteins. While these proteins belong to the same family, they are encoded by different genes, regulate different cellular functions and are localized to specific regions of the body. TSP-5 or Cartilage Oligomeric Matrix Protein (COMP) is the only TSP that has been associated with skeletal disorders in humans, including pseudo. achondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). The pentameric structure of COMP, the evidence that it interacts with multiple cellular proteins, and the recent reports of COMP acting as a 'lattice' to present growth factors to cells, inspired this review of COMP and its interacting partners. In our review, we have compiled the interactions of COMP with other proteins in the cartilage extracellular matrix and summarized their importance in maintaining the structural integrity of cartilage as well as in regulating cellular functions.
KW - Cartilage oligomeric matrix protein
KW - Complement system
KW - Extracellular matrix
KW - Growth factors
KW - Proteases
KW - Receptors
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U2 - 10.1016/j.matbio.2014.06.001
DO - 10.1016/j.matbio.2014.06.001
M3 - Review article
C2 - 24997222
AN - SCOPUS:84908349797
SN - 0945-053X
VL - 37
SP - 102
EP - 111
JO - Matrix Biology
JF - Matrix Biology
ER -