Chronic kidney disease and diabetes

Ronald Pyram; Abhishek Kansara; Mary Ann Banerji; Lisel Loney-Hutchinson

doi:10.1016/j.maturitas.2011.11.009

Chronic kidney disease and diabetes

Ronald Pyram, Abhishek Kansara, Mary Ann Banerji, Lisel Loney-Hutchinson

Research output: Contribution to journal › Review article › peer-review

66 Scopus citations

Abstract

Chronic kidney disease has a significant worldwide prevalence affecting 7.2% of the global adult population with the number dramatically increasing in the elderly. Although the causes are various, diabetes is the most common cause of CKD in the United States and an increasing cause of the same worldwide. Therefore, we chose to focus on diabetic chronic kidney disease in this review. The pathogenesis is multifactorial involving adaptive hyperfiltration, advanced glycosylated end-product synthesis (AGES), prorenin, cytokines, nephrin expression and impaired podocyte-specific insulin signaling. Treatments focus on lifestyle interventions including control of hyperglycemia, hypertension and hyperlipidemia as well treatment of complications and preparation for renal replacement therapy. This review examines the current literature on the epidemiology, pathogenesis, complications and treatment of CKD as well as possible areas of future disease intervention.

Original language	English (US)
Pages (from-to)	94-103
Number of pages	10
Journal	Maturitas
Volume	71
Issue number	2
DOIs	https://doi.org/10.1016/j.maturitas.2011.11.009
State	Published - Feb 2012

Keywords

Chronic renal disease
Diabetes
Glomerular filtration rate
Nephropathy
Renal failure

ASJC Scopus subject areas

Obstetrics and Gynecology
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.maturitas.2011.11.009

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abstract = "Chronic kidney disease has a significant worldwide prevalence affecting 7.2% of the global adult population with the number dramatically increasing in the elderly. Although the causes are various, diabetes is the most common cause of CKD in the United States and an increasing cause of the same worldwide. Therefore, we chose to focus on diabetic chronic kidney disease in this review. The pathogenesis is multifactorial involving adaptive hyperfiltration, advanced glycosylated end-product synthesis (AGES), prorenin, cytokines, nephrin expression and impaired podocyte-specific insulin signaling. Treatments focus on lifestyle interventions including control of hyperglycemia, hypertension and hyperlipidemia as well treatment of complications and preparation for renal replacement therapy. This review examines the current literature on the epidemiology, pathogenesis, complications and treatment of CKD as well as possible areas of future disease intervention.",

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AU - Pyram, Ronald

AU - Kansara, Abhishek

AU - Banerji, Mary Ann

AU - Loney-Hutchinson, Lisel

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N2 - Chronic kidney disease has a significant worldwide prevalence affecting 7.2% of the global adult population with the number dramatically increasing in the elderly. Although the causes are various, diabetes is the most common cause of CKD in the United States and an increasing cause of the same worldwide. Therefore, we chose to focus on diabetic chronic kidney disease in this review. The pathogenesis is multifactorial involving adaptive hyperfiltration, advanced glycosylated end-product synthesis (AGES), prorenin, cytokines, nephrin expression and impaired podocyte-specific insulin signaling. Treatments focus on lifestyle interventions including control of hyperglycemia, hypertension and hyperlipidemia as well treatment of complications and preparation for renal replacement therapy. This review examines the current literature on the epidemiology, pathogenesis, complications and treatment of CKD as well as possible areas of future disease intervention.

AB - Chronic kidney disease has a significant worldwide prevalence affecting 7.2% of the global adult population with the number dramatically increasing in the elderly. Although the causes are various, diabetes is the most common cause of CKD in the United States and an increasing cause of the same worldwide. Therefore, we chose to focus on diabetic chronic kidney disease in this review. The pathogenesis is multifactorial involving adaptive hyperfiltration, advanced glycosylated end-product synthesis (AGES), prorenin, cytokines, nephrin expression and impaired podocyte-specific insulin signaling. Treatments focus on lifestyle interventions including control of hyperglycemia, hypertension and hyperlipidemia as well treatment of complications and preparation for renal replacement therapy. This review examines the current literature on the epidemiology, pathogenesis, complications and treatment of CKD as well as possible areas of future disease intervention.

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KW - Diabetes

KW - Glomerular filtration rate

KW - Nephropathy

KW - Renal failure

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Chronic kidney disease and diabetes

Abstract

Keywords

ASJC Scopus subject areas

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