TY - JOUR
T1 - Comparison of iodine-123-iomazenil spect and technetium-99m-HMPAO-SPECT in Alzheimer's disease
AU - Fukuchi, Kazuki
AU - Hashikawa, Kazuo
AU - Seike, Yujiro
AU - Moriwaki, Hiroshi
AU - Oku, Naohiko
AU - Ishida, Mariko
AU - Fujita, Masahiro
AU - Uehara, Toshiisa
AU - Tanabe, Hirotaka
AU - Kusuoka, Hideo
AU - Nishimura, Tsunehiko
PY - 1997/3
Y1 - 1997/3
N2 - This study was designed to elucidate a central type of benzodiazepine (Bz) receptor distribution in patients with Alzheimer's disease using SPECT with [123I]iornazenil (IMZ). Methods: Eight patients with probable Alzheimer's disease were studied. Benzodiazepine receptor imaging was performed 15 min (early) and 180 min (delayed) after intravenous administration of 167 MBq IMZ, sequentially, using hexamethylpropylene amine oxime (HMPAO) SPECT to evaluate regional cerebral perfusion. Results: Early IMZ-SPECT depicted areas of reduced uptake in sites of decreased cerebral blood flow (CBF), but each area of decreased uptake was extended wider than the area of hypoperfusion. Delayed IMZ-SPECT images demonstrated a similar pattern of decreased area of CBF; the affected region in Bz receptor bindings, however, was clearer and broader compared with that in either HMPAO-SPECT or early IMZ-SPECT. In comparison with the uptakes for the normal cerebral hemisphere (ratio to the contralateral cerebellum) in patients with unilateral cerebral infarction as a control group (n = 4), the patients with Alzheimer's disease showed distinctive bilateral frontal or parietal defects (p < 0.05). Conclusion: Brain SPECT using IMZ may be more sensitive than CBF images in patients with Alzheimer's disease.
AB - This study was designed to elucidate a central type of benzodiazepine (Bz) receptor distribution in patients with Alzheimer's disease using SPECT with [123I]iornazenil (IMZ). Methods: Eight patients with probable Alzheimer's disease were studied. Benzodiazepine receptor imaging was performed 15 min (early) and 180 min (delayed) after intravenous administration of 167 MBq IMZ, sequentially, using hexamethylpropylene amine oxime (HMPAO) SPECT to evaluate regional cerebral perfusion. Results: Early IMZ-SPECT depicted areas of reduced uptake in sites of decreased cerebral blood flow (CBF), but each area of decreased uptake was extended wider than the area of hypoperfusion. Delayed IMZ-SPECT images demonstrated a similar pattern of decreased area of CBF; the affected region in Bz receptor bindings, however, was clearer and broader compared with that in either HMPAO-SPECT or early IMZ-SPECT. In comparison with the uptakes for the normal cerebral hemisphere (ratio to the contralateral cerebellum) in patients with unilateral cerebral infarction as a control group (n = 4), the patients with Alzheimer's disease showed distinctive bilateral frontal or parietal defects (p < 0.05). Conclusion: Brain SPECT using IMZ may be more sensitive than CBF images in patients with Alzheimer's disease.
KW - Alzheimer's disease
KW - Benzodiazepine receptor
KW - Iodine-123- iomazenil
KW - Technetium-99m-HMPAO
UR - http://www.scopus.com/inward/record.url?scp=0030967717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030967717&partnerID=8YFLogxK
M3 - Article
C2 - 9074540
AN - SCOPUS:0030967717
SN - 0161-5505
VL - 38
SP - 467
EP - 470
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
IS - 3
ER -