Coronary abnormalities in hyper-IgE recurrent infection syndrome: Depiction at coronary MDCT angiography

Ahmed M. Gharib; Roderic I. Pettigrew; Abdalla Elagha; Amy Hsu; Pam Welch; Steven M. Holland; Alexandra F. Freeman

doi:10.2214/AJR.09.2623

Coronary abnormalities in hyper-IgE recurrent infection syndrome: Depiction at coronary MDCT angiography

Ahmed M. Gharib, Roderic I. Pettigrew, Abdalla Elagha, Amy Hsu, Pam Welch, Steven M. Holland, Alexandra F. Freeman

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

OBJECTIVE. Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome) is a rare disorder affecting the immune system and connective tissues. The purpose of this study is to describe the coronary abnormalities in genetically confirmed HIES patients as depicted by coronary MDCT angiography (MDCTA). CONCLUSION. Coronary MDCTA has provided an opportunity for noninvasive evaluation of the coronary arteries in patients with HIES. These coronary abnormalities vary from tortuosity to ectatic dilation and focal aneurysms of the coronary arteries. Such an evaluation has potential value in identifying new aspects of this disease and thereby providing better understanding of the pathophysiology of the disorder.

Original language	English (US)
Pages (from-to)	W478-W481
Journal	American Journal of Roentgenology
Volume	193
Issue number	6
DOIs	https://doi.org/10.2214/AJR.09.2623
State	Published - Dec 2009

Keywords

Coronary MDCT angiography
Coronary abnormalities
Coronary aneurysms
Ectatic coronaries
Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome)

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.2214/AJR.09.2623

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abstract = "OBJECTIVE. Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome) is a rare disorder affecting the immune system and connective tissues. The purpose of this study is to describe the coronary abnormalities in genetically confirmed HIES patients as depicted by coronary MDCT angiography (MDCTA). CONCLUSION. Coronary MDCTA has provided an opportunity for noninvasive evaluation of the coronary arteries in patients with HIES. These coronary abnormalities vary from tortuosity to ectatic dilation and focal aneurysms of the coronary arteries. Such an evaluation has potential value in identifying new aspects of this disease and thereby providing better understanding of the pathophysiology of the disorder.",

keywords = "Coronary MDCT angiography, Coronary abnormalities, Coronary aneurysms, Ectatic coronaries, Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome)",

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T1 - Coronary abnormalities in hyper-IgE recurrent infection syndrome

T2 - Depiction at coronary MDCT angiography

AU - Gharib, Ahmed M.

AU - Pettigrew, Roderic I.

AU - Elagha, Abdalla

AU - Hsu, Amy

AU - Welch, Pam

AU - Holland, Steven M.

AU - Freeman, Alexandra F.

PY - 2009/12

Y1 - 2009/12

N2 - OBJECTIVE. Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome) is a rare disorder affecting the immune system and connective tissues. The purpose of this study is to describe the coronary abnormalities in genetically confirmed HIES patients as depicted by coronary MDCT angiography (MDCTA). CONCLUSION. Coronary MDCTA has provided an opportunity for noninvasive evaluation of the coronary arteries in patients with HIES. These coronary abnormalities vary from tortuosity to ectatic dilation and focal aneurysms of the coronary arteries. Such an evaluation has potential value in identifying new aspects of this disease and thereby providing better understanding of the pathophysiology of the disorder.

AB - OBJECTIVE. Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome) is a rare disorder affecting the immune system and connective tissues. The purpose of this study is to describe the coronary abnormalities in genetically confirmed HIES patients as depicted by coronary MDCT angiography (MDCTA). CONCLUSION. Coronary MDCTA has provided an opportunity for noninvasive evaluation of the coronary arteries in patients with HIES. These coronary abnormalities vary from tortuosity to ectatic dilation and focal aneurysms of the coronary arteries. Such an evaluation has potential value in identifying new aspects of this disease and thereby providing better understanding of the pathophysiology of the disorder.

KW - Coronary MDCT angiography

KW - Coronary abnormalities

KW - Coronary aneurysms

KW - Ectatic coronaries

KW - Hyper-IgE recurrent infection syndrome (HIES or Job's syndrome)

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Coronary abnormalities in hyper-IgE recurrent infection syndrome: Depiction at coronary MDCT angiography

Abstract

Keywords

ASJC Scopus subject areas

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