Cytotoxic T lymphocytes as immune-therapy in haematological practice

Ann M. Leen; Helen E. Heslop

doi:10.1111/j.1365-2141.2008.07316.x

Cytotoxic T lymphocytes as immune-therapy in haematological practice

Ann M. Leen, Helen E. Heslop

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Viral infections are a significant cause of morbidity and mortality, particularly in pediatric allogeneic haematopoietic stem cell transplant recipients. Effective therapies are limited and often associated with significant side effects. Adoptive transfer of virus-reactive T cells offers a means of reconstituting antiviral immunity and this approach has been successfully used to prevent and treat cytomegalovirus, Epstein-Barr virus, and adenovirus infections in vivo. This review outlines the clinical trials that have been performed to date, and will describe future initiatives to (a) develop strategies that can increase the breadth of the viruses that can be targeted, and (b) simplify the process to extend this technology to more centers so that cellular therapy to reconstitute immunity can be more widely applied.

Original language	English (US)
Pages (from-to)	169-179
Number of pages	11
Journal	British Journal of Haematology
Volume	143
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.2008.07316.x
State	Published - Oct 2008

Keywords

Immunotherapy
Stem cell transplantation
T cells
Viruses

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2008.07316.x

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AB - Viral infections are a significant cause of morbidity and mortality, particularly in pediatric allogeneic haematopoietic stem cell transplant recipients. Effective therapies are limited and often associated with significant side effects. Adoptive transfer of virus-reactive T cells offers a means of reconstituting antiviral immunity and this approach has been successfully used to prevent and treat cytomegalovirus, Epstein-Barr virus, and adenovirus infections in vivo. This review outlines the clinical trials that have been performed to date, and will describe future initiatives to (a) develop strategies that can increase the breadth of the viruses that can be targeted, and (b) simplify the process to extend this technology to more centers so that cellular therapy to reconstitute immunity can be more widely applied.

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Cytotoxic T lymphocytes as immune-therapy in haematological practice

Abstract

Keywords

ASJC Scopus subject areas

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