Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease

Medicine & Life Sciences

• glycolic acid 85%
• Budesonide 78%
• Silicon 73%
• poly(lactide) 72%
• Inflammatory Bowel Diseases 57%
• Nanoparticles 43%
• In Vitro Techniques 26%
• Anti-Inflammatory Agents 9%
• Intestinal Mucosa 6%
• Drug Liberation 5%
• Intestines 5%
• Gastrointestinal Tract 5%
• Oral Administration 5%
• Mucous Membrane 4%
• Stomach 4%
• Epithelial Cells 4%
• Pressure 3%
• Cytokines 3%
• Pharmaceutical Preparations 2%
• Therapeutics 1%

Chemistry

• Budesonide 100%
• Nanoparticle 30%
• Meso Porosity 26%
• Acid 21%
• pH Value 17%
• Drug 10%
• Anti-Inflammatory Agent 8%
• Antiinflammatory 6%
• Enzyme Activity 5%
• Monolayer 5%
• Dissolution 5%
• Pore 4%
• Surface Area 4%
• Pressure 3%
• Volume 3%