Differences in collagen gene expression in male and female Anterior Cruciate Ligament injured athletes

X. Liu; T. Tingle; David M. Lintner; W. R. Lowe; Q. J. Zhai; Z. P. Luo

doi:10.5604/20831862.894790

Differences in collagen gene expression in male and female Anterior Cruciate Ligament injured athletes

X. Liu, T. Tingle, David M. Lintner, W. R. Lowe, Q. J. Zhai, Z. P. Luo

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Anterior Cruciate Ligament (ACL) injuries occur two to eight times more frequently in women than men. However, it remains unclear whether gender differences exist in ACL at the molecular level. Using reverse transcript polymerase chain reaction (RT-PCR) with histological analysis, the gene expressions of collagen types I and III of fibroblasts from ACLs of 17 male and 17 female athletes with acute ACL tears were studied. Female athletes were found to have a significantly lower gene expression of collagen I. No significant difference was found in type III collagen gene expression between male and female athletes. This finding may help us to explain the higher incidence of ACL injury in female athletes from the molecular perspective.

Original language	English (US)
Pages (from-to)	255-261
Number of pages	7
Journal	Biology of Sport
Volume	26
Issue number	3
DOIs	https://doi.org/10.5604/20831862.894790
State	Published - Jan 1 2009

Keywords

Anterior cruciate ligament (ACL)
Collagen
Gene expression
RT-PCR

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation
Physiology (medical)

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10.5604/20831862.894790

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abstract = "Anterior Cruciate Ligament (ACL) injuries occur two to eight times more frequently in women than men. However, it remains unclear whether gender differences exist in ACL at the molecular level. Using reverse transcript polymerase chain reaction (RT-PCR) with histological analysis, the gene expressions of collagen types I and III of fibroblasts from ACLs of 17 male and 17 female athletes with acute ACL tears were studied. Female athletes were found to have a significantly lower gene expression of collagen I. No significant difference was found in type III collagen gene expression between male and female athletes. This finding may help us to explain the higher incidence of ACL injury in female athletes from the molecular perspective.",

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AU - Liu, X.

AU - Tingle, T.

AU - Lintner, David M.

AU - Lowe, W. R.

AU - Zhai, Q. J.

AU - Luo, Z. P.

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AB - Anterior Cruciate Ligament (ACL) injuries occur two to eight times more frequently in women than men. However, it remains unclear whether gender differences exist in ACL at the molecular level. Using reverse transcript polymerase chain reaction (RT-PCR) with histological analysis, the gene expressions of collagen types I and III of fibroblasts from ACLs of 17 male and 17 female athletes with acute ACL tears were studied. Female athletes were found to have a significantly lower gene expression of collagen I. No significant difference was found in type III collagen gene expression between male and female athletes. This finding may help us to explain the higher incidence of ACL injury in female athletes from the molecular perspective.

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KW - RT-PCR

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Differences in collagen gene expression in male and female Anterior Cruciate Ligament injured athletes

Abstract

Keywords

ASJC Scopus subject areas

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