@article{03a416cfa948432189341232f0942fe0,
title = "Differences in the molecular weight profile of poloxamer 407 affect its ability to redirect intravenously administered colloids to the bone marrow",
abstract = "Samples of poloxamer 407 obtained from different suppliers have been assessed for their ability to redirect model polystyrene colloids to the bone marrow in rabbits. Only poloxamer 407 obtained from one supplier was found to produce the targeting effect seen previously. The variation in the biodistribution patterns produced by the different samples of poloxamer 407 may by caused by differences in the molecular weight distribution of the polymer.",
keywords = "Bone marrow, Microsphere, Poloxamer 407, Rabbit, Rat",
author = "Porter, {C. J.H.} and Moghimi, {S. M.} and Davies, {M. C.} and Davis, {S. S.} and L. Illum",
note = "Funding Information: We are grateful to RAPRA Technology Ltd, Shrewsbury, U.K., for their help in performing raised temperature gel-permeation chromatography, Professor E. Schacht, Laboratory of Organic Chemistry, Rijksuniversiteit Gent, Belgium, for his expert assistance with the NMR studies, and to the SERC, U.K., for financial support. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "1992",
month = jun,
day = "30",
doi = "10.1016/0378-5173(82)90033-3",
language = "English (US)",
volume = "83",
pages = "273--276",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-3",
}