Efficacy of tedizolid against enterococci and staphylococci, including CFR strains, in a mouse peritonitis model

Kavindra V. Singh, Cesar A. Arias, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

In a mouse peritonitis model, tedizolid was comparable to linezolid and daptomycin against an Enterococcus faecium strain (VANr, AMPr), an Enterococcus faecalis strain, and a methicillin-resistant Staphylococcus aureus (MRSA) strain with and without cfr. Against a cfr(B) E. faecium, tedizolid was inferior in vivo to linezolid and daptomycin, despite an 4-fold lower MIC.

Original languageEnglish (US)
Article numbere02627-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number4
DOIs
StatePublished - Apr 2019

Keywords

  • Mouse peritonitis
  • Tedizolid

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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