Elevated Cyclic GMP Levels in Rabbit Atria Following Vagal Stimulation and Acetylcholine Treatment (39484)

Gregory D. Fink; Richard J. Paddock; George M. Rodgers; Ronald W. Busuttil; William J. George

doi:10.3181/00379727-153-39484

Elevated Cyclic GMP Levels in Rabbit Atria Following Vagal Stimulation and Acetylcholine Treatment (39484)

Gregory D. Fink, Richard J. Paddock, George M. Rodgers, Ronald W. Busuttil, William J. George

Research output: Contribution to journal › Article › peer-review

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Abstract

In studies designed to investigate the effects of cholinergic stimuli on myocardial cyclic nucleotide content and myocardial performance, an isolated paced rabbit atrial preparation and an in situ rabbit right atrium/vagus nerve preparation were utilized. Following vagal stimulation or ace-tylcholine treatment, increases in atrial cGMP content preceded or occurred at the same time as the mechanical changes associated with cholinergic stimulation. Atrial cAMP content was not affected by these stimuli. Increased cGMP levels were correlated with the decreased force of contraction, but not the decreased chronotropic effects of cholinergic stimulation. These data support the concept that modifications in cardiac performance may be mediated by cGMP. In particular, cGMP may mediate the pharmacological effects of acetylcholine as well as the physiological effects of vagal stimulation.

Original language	English (US)
Pages (from-to)	78-82
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	153
Issue number	1
DOIs	https://doi.org/10.3181/00379727-153-39484
State	Published - Oct 1976

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Elevated Cyclic GMP Levels in Rabbit Atria Following Vagal Stimulation and Acetylcholine Treatment (39484)",

abstract = "In studies designed to investigate the effects of cholinergic stimuli on myocardial cyclic nucleotide content and myocardial performance, an isolated paced rabbit atrial preparation and an in situ rabbit right atrium/vagus nerve preparation were utilized. Following vagal stimulation or ace-tylcholine treatment, increases in atrial cGMP content preceded or occurred at the same time as the mechanical changes associated with cholinergic stimulation. Atrial cAMP content was not affected by these stimuli. Increased cGMP levels were correlated with the decreased force of contraction, but not the decreased chronotropic effects of cholinergic stimulation. These data support the concept that modifications in cardiac performance may be mediated by cGMP. In particular, cGMP may mediate the pharmacological effects of acetylcholine as well as the physiological effects of vagal stimulation.",

author = "Fink, {Gregory D.} and Paddock, {Richard J.} and Rodgers, {George M.} and Busuttil, {Ronald W.} and George, {William J.}",

note = "Funding Information: This investigation was supported in part by USPHS Grants HL 13776, HL 14976, and an award from the Edward G. Schlieder Foundation. ",

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AU - Paddock, Richard J.

AU - Rodgers, George M.

AU - Busuttil, Ronald W.

AU - George, William J.

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AB - In studies designed to investigate the effects of cholinergic stimuli on myocardial cyclic nucleotide content and myocardial performance, an isolated paced rabbit atrial preparation and an in situ rabbit right atrium/vagus nerve preparation were utilized. Following vagal stimulation or ace-tylcholine treatment, increases in atrial cGMP content preceded or occurred at the same time as the mechanical changes associated with cholinergic stimulation. Atrial cAMP content was not affected by these stimuli. Increased cGMP levels were correlated with the decreased force of contraction, but not the decreased chronotropic effects of cholinergic stimulation. These data support the concept that modifications in cardiac performance may be mediated by cGMP. In particular, cGMP may mediate the pharmacological effects of acetylcholine as well as the physiological effects of vagal stimulation.

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Elevated Cyclic GMP Levels in Rabbit Atria Following Vagal Stimulation and Acetylcholine Treatment (39484)

Abstract

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