Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil

Dayane Azevedo Padilha; Vilmar Benetti Filho; Renato Simões Moreira; Tatiany Aparecida Teixeira Soratto; Guilherme Augusto Maia; Ana Paula Christoff; Fernando Hartmann Barazzetti; Marcos André Schörner; Fernanda Luiza Ferrari; Carolina Leite Martins; Eric Kazuo Kawagoe; Julia Kinetz Wachter; Paula Sachet; Antuani Rafael Baptistella; Aline Daiane Schlindwein; Bruna Kellet Coelho; Sandra Bianchini Fernandes; Darcita Buerger Rovaris; Marlei Pickler Debiasi Dos Anjos; Fernanda Rosene Melo; Bianca Bittencourt; Sthefani Cunha; Karine Lena Meneghetti; Nestor Wendt; Tâmela Zamboni Madaloz; Marcus Vinícius Duarte Rodrigues; Doris Sobral Marques Souza; Milene Höehr de Moraes; Rodrigo de Paula Baptista; Guilherme Toledo-Silva; Guilherme Razzera; Edmundo Carlos Grisard; Patricia Hermes Stoco; Luiz Felipe Valter de Oliveira; Maria Luiza Bazzo; Gislaine Fongaro; Glauber Wagner

doi:10.3390/v14040695

Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil

Dayane Azevedo Padilha, Vilmar Benetti Filho, Renato Simões Moreira, Tatiany Aparecida Teixeira Soratto, Guilherme Augusto Maia, Ana Paula Christoff, Fernando Hartmann Barazzetti, Marcos André Schörner, Fernanda Luiza Ferrari, Carolina Leite Martins, Eric Kazuo Kawagoe, Julia Kinetz Wachter, Paula Sachet, Antuani Rafael Baptistella, Aline Daiane Schlindwein, Bruna Kellet Coelho, Sandra Bianchini Fernandes, Darcita Buerger Rovaris, Marlei Pickler Debiasi Dos Anjos, Fernanda Rosene MeloBianca Bittencourt, Sthefani Cunha, Karine Lena Meneghetti, Nestor Wendt, Tâmela Zamboni Madaloz, Marcus Vinícius Duarte Rodrigues, Doris Sobral Marques Souza, Milene Höehr de Moraes, Rodrigo de Paula Baptista, Guilherme Toledo-Silva, Guilherme Razzera, Edmundo Carlos Grisard, Patricia Hermes Stoco, Luiz Felipe Valter de Oliveira, Maria Luiza Bazzo, Gislaine Fongaro, Glauber Wagner

Houston Methodist

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The western mesoregion of the state of Santa Catarina (SC), Southern Brazil, was heavily affected as a whole by the COVID-19 pandemic in early 2021. This study aimed to evaluate the dynamics of the SARS-CoV-2 virus spreading patterns in the SC state from March 2020 to April 2021 using genomic surveillance. During this period, there were 23 distinct variants, including Beta and Gamma, among which the Gamma and related lineages were predominant in the second pandemic wave within SC. A regionalization of P.1-like-II in the Western SC region was observed, concomitant to the increase in cases, mortality, and the case fatality rate (CFR) index. This is the first evidence of the regionalization of the SARS-CoV-2 transmission in SC and it highlights the importance of tracking the variants, dispersion, and impact of SARS-CoV-2 on the public health systems.

Original language	English (US)
Article number	695
Journal	Viruses
Volume	14
Issue number	4
DOIs	https://doi.org/10.3390/v14040695
State	Published - Mar 27 2022

Keywords

SARS-CoV-2
SARS-CoV-2 P.1 variant
genome
surveillance
COVID-19/epidemiology
Pandemics
SARS-CoV-2/genetics
Humans
Brazil/epidemiology
Mutation
Phylogeny
Spike Glycoprotein, Coronavirus/genetics

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v14040695

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Padilha, D. A., Filho, V. B., Moreira, R. S., Soratto, T. A. T., Maia, G. A., Christoff, A. P., Barazzetti, F. H., Schörner, M. A., Ferrari, F. L., Martins, C. L., Kawagoe, E. K., Wachter, J. K., Sachet, P., Baptistella, A. R., Schlindwein, A. D., Coelho, B. K., Fernandes, S. B., Rovaris, D. B., Dos Anjos, M. P. D., ... Wagner, G. (2022). Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil. Viruses, 14(4), Article 695. https://doi.org/10.3390/v14040695

Padilha, DA, Filho, VB, Moreira, RS, Soratto, TAT, Maia, GA, Christoff, AP, Barazzetti, FH, Schörner, MA, Ferrari, FL, Martins, CL, Kawagoe, EK, Wachter, JK, Sachet, P, Baptistella, AR, Schlindwein, AD, Coelho, BK, Fernandes, SB, Rovaris, DB, Dos Anjos, MPD, Melo, FR, Bittencourt, B, Cunha, S, Meneghetti, KL, Wendt, N, Madaloz, TZ, Rodrigues, MVD, Souza, DSM, de Moraes, MH, Baptista, RDP, Toledo-Silva, G, Razzera, G, Grisard, EC, Stoco, PH, de Oliveira, LFV, Bazzo, ML, Fongaro, G & Wagner, G 2022, 'Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil', Viruses, vol. 14, no. 4, 695. https://doi.org/10.3390/v14040695

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title = "Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil",

abstract = "The western mesoregion of the state of Santa Catarina (SC), Southern Brazil, was heavily affected as a whole by the COVID-19 pandemic in early 2021. This study aimed to evaluate the dynamics of the SARS-CoV-2 virus spreading patterns in the SC state from March 2020 to April 2021 using genomic surveillance. During this period, there were 23 distinct variants, including Beta and Gamma, among which the Gamma and related lineages were predominant in the second pandemic wave within SC. A regionalization of P.1-like-II in the Western SC region was observed, concomitant to the increase in cases, mortality, and the case fatality rate (CFR) index. This is the first evidence of the regionalization of the SARS-CoV-2 transmission in SC and it highlights the importance of tracking the variants, dispersion, and impact of SARS-CoV-2 on the public health systems.",

keywords = "SARS-CoV-2, SARS-CoV-2 P.1 variant, genome, surveillance, COVID-19/epidemiology, Pandemics, SARS-CoV-2/genetics, Humans, Brazil/epidemiology, Mutation, Phylogeny, Spike Glycoprotein, Coronavirus/genetics",

author = "Padilha, {Dayane Azevedo} and Filho, {Vilmar Benetti} and Moreira, {Renato Sim{\~o}es} and Soratto, {Tatiany Aparecida Teixeira} and Maia, {Guilherme Augusto} and Christoff, {Ana Paula} and Barazzetti, {Fernando Hartmann} and Sch{\"o}rner, {Marcos Andr{\'e}} and Ferrari, {Fernanda Luiza} and Martins, {Carolina Leite} and Kawagoe, {Eric Kazuo} and Wachter, {Julia Kinetz} and Paula Sachet and Baptistella, {Antuani Rafael} and Schlindwein, {Aline Daiane} and Coelho, {Bruna Kellet} and Fernandes, {Sandra Bianchini} and Rovaris, {Darcita Buerger} and {Dos Anjos}, {Marlei Pickler Debiasi} and Melo, {Fernanda Rosene} and Bianca Bittencourt and Sthefani Cunha and Meneghetti, {Karine Lena} and Nestor Wendt and Madaloz, {T{\^a}mela Zamboni} and Rodrigues, {Marcus Vin{\'i}cius Duarte} and Souza, {Doris Sobral Marques} and {de Moraes}, {Milene H{\"o}ehr} and Baptista, {Rodrigo de Paula} and Guilherme Toledo-Silva and Guilherme Razzera and Grisard, {Edmundo Carlos} and Stoco, {Patricia Hermes} and {de Oliveira}, {Luiz Felipe Valter} and Bazzo, {Maria Luiza} and Gislaine Fongaro and Glauber Wagner",

note = "Funding Information: Funding: This research was funded by Santa Catarina Research Foundation (Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa e Inova{\c c}{\~a}o of Santa Catarina, FAPESC, Santa Catarina, Brazil) (grant number COV2020051000065), CAPES (Coordination for the Improvement of Higher Education Personnel, Brazil), CNPq (National Council for Scientific and Technological Development, Brazil) and UFSC (Federal University of Santa Catarina). DAP, VBF, TATP, GAM, CLM, EKK, and TZM were recipients of FAPESC, CAPES, or CNPq scholarships. The APC was funded by Santa Catarina Research Foundation (Funda{\c c}{\~a}o de Amparo {\`a} Pesquisa e Inova{\c c}{\~a}o of Santa Catarina, FAPESC, Santa Catarina, Brazil), Federal University of Santa Catarina (UFSC) Project SIGPEX 201917940, and Brazilian Society of Virology. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = mar,

day = "27",

doi = "10.3390/v14040695",

language = "English (US)",

volume = "14",

journal = "Viruses",

issn = "1999-4915",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil

AU - Padilha, Dayane Azevedo

AU - Filho, Vilmar Benetti

AU - Moreira, Renato Simões

AU - Soratto, Tatiany Aparecida Teixeira

AU - Maia, Guilherme Augusto

AU - Christoff, Ana Paula

AU - Barazzetti, Fernando Hartmann

AU - Schörner, Marcos André

AU - Ferrari, Fernanda Luiza

AU - Martins, Carolina Leite

AU - Kawagoe, Eric Kazuo

AU - Wachter, Julia Kinetz

AU - Sachet, Paula

AU - Baptistella, Antuani Rafael

AU - Schlindwein, Aline Daiane

AU - Coelho, Bruna Kellet

AU - Fernandes, Sandra Bianchini

AU - Rovaris, Darcita Buerger

AU - Dos Anjos, Marlei Pickler Debiasi

AU - Melo, Fernanda Rosene

AU - Bittencourt, Bianca

AU - Cunha, Sthefani

AU - Meneghetti, Karine Lena

AU - Wendt, Nestor

AU - Madaloz, Tâmela Zamboni

AU - Rodrigues, Marcus Vinícius Duarte

AU - Souza, Doris Sobral Marques

AU - de Moraes, Milene Höehr

AU - Baptista, Rodrigo de Paula

AU - Toledo-Silva, Guilherme

AU - Razzera, Guilherme

AU - Grisard, Edmundo Carlos

AU - Stoco, Patricia Hermes

AU - de Oliveira, Luiz Felipe Valter

AU - Bazzo, Maria Luiza

AU - Fongaro, Gislaine

AU - Wagner, Glauber

N1 - Funding Information: Funding: This research was funded by Santa Catarina Research Foundation (Fundação de Amparo à Pesquisa e Inovação of Santa Catarina, FAPESC, Santa Catarina, Brazil) (grant number COV2020051000065), CAPES (Coordination for the Improvement of Higher Education Personnel, Brazil), CNPq (National Council for Scientific and Technological Development, Brazil) and UFSC (Federal University of Santa Catarina). DAP, VBF, TATP, GAM, CLM, EKK, and TZM were recipients of FAPESC, CAPES, or CNPq scholarships. The APC was funded by Santa Catarina Research Foundation (Fundação de Amparo à Pesquisa e Inovação of Santa Catarina, FAPESC, Santa Catarina, Brazil), Federal University of Santa Catarina (UFSC) Project SIGPEX 201917940, and Brazilian Society of Virology. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/3/27

Y1 - 2022/3/27

N2 - The western mesoregion of the state of Santa Catarina (SC), Southern Brazil, was heavily affected as a whole by the COVID-19 pandemic in early 2021. This study aimed to evaluate the dynamics of the SARS-CoV-2 virus spreading patterns in the SC state from March 2020 to April 2021 using genomic surveillance. During this period, there were 23 distinct variants, including Beta and Gamma, among which the Gamma and related lineages were predominant in the second pandemic wave within SC. A regionalization of P.1-like-II in the Western SC region was observed, concomitant to the increase in cases, mortality, and the case fatality rate (CFR) index. This is the first evidence of the regionalization of the SARS-CoV-2 transmission in SC and it highlights the importance of tracking the variants, dispersion, and impact of SARS-CoV-2 on the public health systems.

AB - The western mesoregion of the state of Santa Catarina (SC), Southern Brazil, was heavily affected as a whole by the COVID-19 pandemic in early 2021. This study aimed to evaluate the dynamics of the SARS-CoV-2 virus spreading patterns in the SC state from March 2020 to April 2021 using genomic surveillance. During this period, there were 23 distinct variants, including Beta and Gamma, among which the Gamma and related lineages were predominant in the second pandemic wave within SC. A regionalization of P.1-like-II in the Western SC region was observed, concomitant to the increase in cases, mortality, and the case fatality rate (CFR) index. This is the first evidence of the regionalization of the SARS-CoV-2 transmission in SC and it highlights the importance of tracking the variants, dispersion, and impact of SARS-CoV-2 on the public health systems.

KW - SARS-CoV-2

KW - SARS-CoV-2 P.1 variant

KW - genome

KW - surveillance

KW - COVID-19/epidemiology

KW - Pandemics

KW - SARS-CoV-2/genetics

KW - Humans

KW - Brazil/epidemiology

KW - Mutation

KW - Phylogeny

KW - Spike Glycoprotein, Coronavirus/genetics

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SN - 1999-4915

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JF - Viruses

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Emergence of Two Distinct SARS-CoV-2 Gamma Variants and the Rapid Spread of P.1-like-II SARS-CoV-2 during the Second Wave of COVID-19 in Santa Catarina, Southern Brazil

Abstract

Keywords

ASJC Scopus subject areas

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