TY - JOUR
T1 - Extracellular Matrix and Colorectal Cancer
T2 - How Surrounding Microenvironment Affects Cancer Cell Behavior?
AU - Crotti, Sara
AU - Piccoli, Martina
AU - Rizzolio, Flavio
AU - Giordano, Antonio
AU - Nitti, Donato
AU - Agostini, Marco
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Colorectal cancer (CRC) whit more than a million of new cases per year is one of the most common registered cancers worldwide with few treatment options especially for advanced and metastatic patients.The tumor microenvironment is composed by extracellular matrix (ECM), cells, and interstitial fluids. Among all these constituents, in the last years an increased interest around the ECM and its potential role in cancer tumorigenesis is arisen. During cancer progression the ECM structure and composition became disorganized, allowing cellular transformation and metastasis. Up to now, the focus has mainly been on the characterization of CRC microenvironment analyzing separately structural ECM components or cell secretome modifications. A more extensive view that interconnects these aspects should be addressed. In this review, biochemical (secretome) and biomechanical (structure and architecture) changes of tumor microenvironment will be discussed, giving suggestions on how these changes can affect cancer cell behavior. J. Cell. Physiol. 232: 967–975, 2017.
AB - Colorectal cancer (CRC) whit more than a million of new cases per year is one of the most common registered cancers worldwide with few treatment options especially for advanced and metastatic patients.The tumor microenvironment is composed by extracellular matrix (ECM), cells, and interstitial fluids. Among all these constituents, in the last years an increased interest around the ECM and its potential role in cancer tumorigenesis is arisen. During cancer progression the ECM structure and composition became disorganized, allowing cellular transformation and metastasis. Up to now, the focus has mainly been on the characterization of CRC microenvironment analyzing separately structural ECM components or cell secretome modifications. A more extensive view that interconnects these aspects should be addressed. In this review, biochemical (secretome) and biomechanical (structure and architecture) changes of tumor microenvironment will be discussed, giving suggestions on how these changes can affect cancer cell behavior. J. Cell. Physiol. 232: 967–975, 2017.
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U2 - 10.1002/jcp.25658
DO - 10.1002/jcp.25658
M3 - Review article
AN - SCOPUS:85000868515
SN - 0021-9541
VL - 232
SP - 967
EP - 975
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 5
ER -