TY - JOUR
T1 - Fifty years of cycling
AU - Biggins, Sue
AU - Hartwell, Lee
AU - Toczyski, David
N1 - Publisher Copyright:
© 2020 Biggins et al.
PY - 2020/12/15
Y1 - 2020/12/15
N2 - Fifty years ago, the first isolation of conditional budding yeast mutants that were defective in cell division was reported. Looking back, we now know that the analysis of these mutants revealed the molecular mechanisms and logic of the cell cycle, identified key regulatory enzymes that drive the cell cycle, elucidated structural components that underly essential cell cycle processes, and influenced our thinking about cancer and other diseases. Here, we briefly summarize what was concluded about the coordination of the cell cycle 50 years ago and how that relates to our current understanding of the molecular events that have since been elucidated.
AB - Fifty years ago, the first isolation of conditional budding yeast mutants that were defective in cell division was reported. Looking back, we now know that the analysis of these mutants revealed the molecular mechanisms and logic of the cell cycle, identified key regulatory enzymes that drive the cell cycle, elucidated structural components that underly essential cell cycle processes, and influenced our thinking about cancer and other diseases. Here, we briefly summarize what was concluded about the coordination of the cell cycle 50 years ago and how that relates to our current understanding of the molecular events that have since been elucidated.
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U2 - 10.1091/mbc.E20-07-0495
DO - 10.1091/mbc.E20-07-0495
M3 - Article
C2 - 33320706
AN - SCOPUS:85097922415
SN - 1059-1524
VL - 31
SP - 2868
EP - 2870
JO - Molecular Biology of the Cell
JF - Molecular Biology of the Cell
IS - 26
ER -