Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers

William W. Yu; Emmanuel Chang; Joshua C. Falkner; Junyan Zhang; Ali M. Al-Somali; Christie M. Sayes; Judah Johns; Rebekah Drezek; Vicki L. Colvin

doi:10.1021/ja067184n

Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers

William W. Yu, Emmanuel Chang, Joshua C. Falkner, Junyan Zhang, Ali M. Al-Somali, Christie M. Sayes, Judah Johns, Rebekah Drezek, Vicki L. Colvin

Research output: Contribution to journal › Article › peer-review

501 Scopus citations

Abstract

High-quality nanocrystals formed in organic solvents can be completely solubilized in water using amphiphilic copolymers containing poly(ethylene glycol) or PEG. These copolymers are generated using a maleic anhydride coupling scheme that permits the coupling of a wide variety of PEG polymers, both unfunctionalized and functionalized, to hydrophobic tails. Thermogravimetric analysis, size exclusion chromatography, cryogenic transmission electron microscopy, and infrared spectroscopy all indicate that the copolymers effectively coat the nanocrystals surfaces. The composite nanocrystal-polymer assemblies can be targeted to recognize cancer cells with Her2 receptor and are biocompatible if their surface coatings contain PEG. In the particular case of semiconductor nanocrystals (e.g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions.

Original language	English (US)
Pages (from-to)	2871-2879
Number of pages	9
Journal	Journal of the American Chemical Society
Volume	129
Issue number	10
DOIs	https://doi.org/10.1021/ja067184n
State	Published - Mar 14 2007

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "High-quality nanocrystals formed in organic solvents can be completely solubilized in water using amphiphilic copolymers containing poly(ethylene glycol) or PEG. These copolymers are generated using a maleic anhydride coupling scheme that permits the coupling of a wide variety of PEG polymers, both unfunctionalized and functionalized, to hydrophobic tails. Thermogravimetric analysis, size exclusion chromatography, cryogenic transmission electron microscopy, and infrared spectroscopy all indicate that the copolymers effectively coat the nanocrystals surfaces. The composite nanocrystal-polymer assemblies can be targeted to recognize cancer cells with Her2 receptor and are biocompatible if their surface coatings contain PEG. In the particular case of semiconductor nanocrystals (e.g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions.",

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AU - Yu, William W.

AU - Chang, Emmanuel

AU - Falkner, Joshua C.

AU - Zhang, Junyan

AU - Al-Somali, Ali M.

AU - Sayes, Christie M.

AU - Johns, Judah

AU - Drezek, Rebekah

AU - Colvin, Vicki L.

PY - 2007/3/14

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AB - High-quality nanocrystals formed in organic solvents can be completely solubilized in water using amphiphilic copolymers containing poly(ethylene glycol) or PEG. These copolymers are generated using a maleic anhydride coupling scheme that permits the coupling of a wide variety of PEG polymers, both unfunctionalized and functionalized, to hydrophobic tails. Thermogravimetric analysis, size exclusion chromatography, cryogenic transmission electron microscopy, and infrared spectroscopy all indicate that the copolymers effectively coat the nanocrystals surfaces. The composite nanocrystal-polymer assemblies can be targeted to recognize cancer cells with Her2 receptor and are biocompatible if their surface coatings contain PEG. In the particular case of semiconductor nanocrystals (e.g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions.

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Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers

Abstract

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