Gene-marking and haemopoietic stem-cell transplantation

H. E. Heslop; C. M. Rooney; M. K. Brenner

doi:10.1016/S0268-960X(95)90013-6

Gene-marking and haemopoietic stem-cell transplantation

H. E. Heslop, C. M. Rooney, M. K. Brenner

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Gene transfer has allowed a number of biological issues in haematopoietic stem-cell transplantation to be addressed. Gene-marking studies have shown that residual malignant cells in infused marrow may contribute to relapse in acute myeloid leukaemia, neuroblastoma and chronic myeloid leukaemia. Double gene-marking techniques with distinguishable retroviral vectors are being used to compare purging techniques and the reconstitution of different sources of stem cells. In allogeneic bone-marrow transplantation, gene-marking has demonstrated that adoptively transferred cytotoxic T cells can persist and reconstitute antiviral immunity.

Original language	English (US)
Pages (from-to)	220-225
Number of pages	6
Journal	Blood Reviews
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/S0268-960X(95)90013-6
State	Published - Dec 1995

ASJC Scopus subject areas

Hematology
Oncology

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10.1016/S0268-960X(95)90013-6

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title = "Gene-marking and haemopoietic stem-cell transplantation",

abstract = "Gene transfer has allowed a number of biological issues in haematopoietic stem-cell transplantation to be addressed. Gene-marking studies have shown that residual malignant cells in infused marrow may contribute to relapse in acute myeloid leukaemia, neuroblastoma and chronic myeloid leukaemia. Double gene-marking techniques with distinguishable retroviral vectors are being used to compare purging techniques and the reconstitution of different sources of stem cells. In allogeneic bone-marrow transplantation, gene-marking has demonstrated that adoptively transferred cytotoxic T cells can persist and reconstitute antiviral immunity.",

author = "Heslop, {H. E.} and Rooney, {C. M.} and Brenner, {M. K.}",

note = "Funding Information: This research was supported in part by NIH grants CA 21684, CA 20180, CA 21745 (CORE) and by the American Lebanese Syrian Associated Charities (ALSAC).",

year = "1995",

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doi = "10.1016/S0268-960X(95)90013-6",

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T1 - Gene-marking and haemopoietic stem-cell transplantation

AU - Heslop, H. E.

AU - Rooney, C. M.

AU - Brenner, M. K.

N1 - Funding Information: This research was supported in part by NIH grants CA 21684, CA 20180, CA 21745 (CORE) and by the American Lebanese Syrian Associated Charities (ALSAC).

PY - 1995/12

Y1 - 1995/12

N2 - Gene transfer has allowed a number of biological issues in haematopoietic stem-cell transplantation to be addressed. Gene-marking studies have shown that residual malignant cells in infused marrow may contribute to relapse in acute myeloid leukaemia, neuroblastoma and chronic myeloid leukaemia. Double gene-marking techniques with distinguishable retroviral vectors are being used to compare purging techniques and the reconstitution of different sources of stem cells. In allogeneic bone-marrow transplantation, gene-marking has demonstrated that adoptively transferred cytotoxic T cells can persist and reconstitute antiviral immunity.

AB - Gene transfer has allowed a number of biological issues in haematopoietic stem-cell transplantation to be addressed. Gene-marking studies have shown that residual malignant cells in infused marrow may contribute to relapse in acute myeloid leukaemia, neuroblastoma and chronic myeloid leukaemia. Double gene-marking techniques with distinguishable retroviral vectors are being used to compare purging techniques and the reconstitution of different sources of stem cells. In allogeneic bone-marrow transplantation, gene-marking has demonstrated that adoptively transferred cytotoxic T cells can persist and reconstitute antiviral immunity.

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JO - Blood Reviews

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Gene-marking and haemopoietic stem-cell transplantation

Abstract

ASJC Scopus subject areas

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