Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

Tim Wiltshire; Mathew T. Pletcher; Serge Batalov; S. Whitney Barnes; Lisa M. Tarantino; Michael P. Cooke; Hua Wu; Kevin Smylie; Andrey Santrosyan; Neal G. Copeland; Nancy A. Jenkins; Francis Kalush; Richard J. Mural; Richard J. Glynne; Steve A. Kay; Mark D. Adams; Colin F. Fletcher

doi:10.1073/pnas.0130101100

Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

Tim Wiltshire, Mathew T. Pletcher, Serge Batalov, S. Whitney Barnes, Lisa M. Tarantino, Michael P. Cooke, Hua Wu, Kevin Smylie, Andrey Santrosyan, Neal G. Copeland, Nancy A. Jenkins, Francis Kalush, Richard J. Mural, Richard J. Glynne, Steve A. Kay, Mark D. Adams, Colin F. Fletcher

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213 Scopus citations

Abstract

The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.

Original language	English (US)
Pages (from-to)	3380-3385
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	6
DOIs	https://doi.org/10.1073/pnas.0130101100
State	Published - Mar 18 2003

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Wiltshire, T., Pletcher, M. T., Batalov, S., Whitney Barnes, S., Tarantino, L. M., Cooke, M. P., Wu, H., Smylie, K., Santrosyan, A., Copeland, N. G., Jenkins, N. A., Kalush, F., Mural, R. J., Glynne, R. J., Kay, S. A., Adams, M. D., & Fletcher, C. F. (2003). Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proceedings of the National Academy of Sciences of the United States of America, 100(6), 3380-3385. https://doi.org/10.1073/pnas.0130101100

Wiltshire, T, Pletcher, MT, Batalov, S, Whitney Barnes, S, Tarantino, LM, Cooke, MP, Wu, H, Smylie, K, Santrosyan, A, Copeland, NG , Jenkins, NA, Kalush, F, Mural, RJ, Glynne, RJ, Kay, SA, Adams, MD & Fletcher, CF 2003, 'Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse', Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 6, pp. 3380-3385. https://doi.org/10.1073/pnas.0130101100

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abstract = "The nature and organization of polymorphisms, or differences, between genomes of individuals are of great interest, because these variations can be associated with or even underlie phenotypic traits, including disease susceptibility. To gain insight into the genetic and evolutionary factors influencing such biological variation, we have examined the arrangement (haplotype) of single-nucleotide polymorphisms across the genomes of eight inbred strains of mice. These analyses define blocks of high or low diversity, often extending across tens of megabases that are delineated by abrupt transitions. These observations provide a striking contrast to the haplotype structure of the human genome.",

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AU - Cooke, Michael P.

AU - Wu, Hua

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Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse

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