High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life

Irene J. Mikhail; Julia B. Purdy; David S. Dimock; Vijaya M. Thomas; Nancy A. Muldoon; Sarah B. Clauss; Russell R. Cross; Roderic I. Pettigrew; Rohan Hazra; Colleen Hadigan; Ahmed M. Gharib

doi:10.1097/INF.0b013e31820f6575

High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life

Irene J. Mikhail, Julia B. Purdy, David S. Dimock, Vijaya M. Thomas, Nancy A. Muldoon, Sarah B. Clauss, Russell R. Cross, Roderic I. Pettigrew, Rohan Hazra, Colleen Hadigan, Ahmed M. Gharib

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17 Scopus citations

Abstract

We completed a cross-sectional study of individuals infected with human immunodeficiency virus in early childhood using cardiac magnetic resonance imaging and magnetic resonance angiography. Coronary artery abnormality (CAA) was defined by the presence of luminal narrowing and irregularity of the coronary vessel wall. More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis.

Original language	English (US)
Pages (from-to)	712-714
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	8
DOIs	https://doi.org/10.1097/INF.0b013e31820f6575
State	Published - Aug 2011

Keywords

HIV
cardiovascular
coronary MRI
coronary artery abnormality
pediatric

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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Mikhail, I. J., Purdy, J. B., Dimock, D. S., Thomas, V. M., Muldoon, N. A., Clauss, S. B., Cross, R. R., Pettigrew, R. I., Hazra, R., Hadigan, C., & Gharib, A. M. (2011). High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life. Pediatric Infectious Disease Journal, 30(8), 712-714. https://doi.org/10.1097/INF.0b013e31820f6575

Mikhail, IJ, Purdy, JB, Dimock, DS, Thomas, VM, Muldoon, NA, Clauss, SB, Cross, RR, Pettigrew, RI, Hazra, R, Hadigan, C & Gharib, AM 2011, 'High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life', Pediatric Infectious Disease Journal, vol. 30, no. 8, pp. 712-714. https://doi.org/10.1097/INF.0b013e31820f6575

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title = "High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life",

abstract = "We completed a cross-sectional study of individuals infected with human immunodeficiency virus in early childhood using cardiac magnetic resonance imaging and magnetic resonance angiography. Coronary artery abnormality (CAA) was defined by the presence of luminal narrowing and irregularity of the coronary vessel wall. More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis.",

keywords = "HIV, cardiovascular, coronary MRI, coronary artery abnormality, pediatric",

author = "Mikhail, {Irene J.} and Purdy, {Julia B.} and Dimock, {David S.} and Thomas, {Vijaya M.} and Muldoon, {Nancy A.} and Clauss, {Sarah B.} and Cross, {Russell R.} and Pettigrew, {Roderic I.} and Rohan Hazra and Colleen Hadigan and Gharib, {Ahmed M.}",

note = "Funding Information: Supported by Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. ",

year = "2011",

month = aug,

doi = "10.1097/INF.0b013e31820f6575",

language = "English (US)",

volume = "30",

pages = "712--714",

journal = "Pediatric Infectious Disease Journal",

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T1 - High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life

AU - Mikhail, Irene J.

AU - Purdy, Julia B.

AU - Dimock, David S.

AU - Thomas, Vijaya M.

AU - Muldoon, Nancy A.

AU - Clauss, Sarah B.

AU - Cross, Russell R.

AU - Pettigrew, Roderic I.

AU - Hazra, Rohan

AU - Hadigan, Colleen

AU - Gharib, Ahmed M.

N1 - Funding Information: Supported by Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

PY - 2011/8

Y1 - 2011/8

N2 - We completed a cross-sectional study of individuals infected with human immunodeficiency virus in early childhood using cardiac magnetic resonance imaging and magnetic resonance angiography. Coronary artery abnormality (CAA) was defined by the presence of luminal narrowing and irregularity of the coronary vessel wall. More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis.

AB - We completed a cross-sectional study of individuals infected with human immunodeficiency virus in early childhood using cardiac magnetic resonance imaging and magnetic resonance angiography. Coronary artery abnormality (CAA) was defined by the presence of luminal narrowing and irregularity of the coronary vessel wall. More than 50% of participants (14/27) had evidence of CAA. Individuals had a high rate of CAA, suggesting possible early atherosclerosis.

KW - HIV

KW - cardiovascular

KW - coronary MRI

KW - coronary artery abnormality

KW - pediatric

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High rate of coronary artery abnormalities in adolescents and young adults infected with human immunodeficiency virus early in life

Abstract

Keywords

ASJC Scopus subject areas

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