Immunoreactive somatostatin in human pancreatic secretion

Atilla Ertan; Tomohiko Taminato; Kemal Akdamar; Jerome Ryan; Naurang M. Agrawal; Andrew V. Schally; Akira Arimura

doi:10.1210/jcem-52-3-589

Immunoreactive somatostatin in human pancreatic secretion

Atilla Ertan, Tomohiko Taminato, Kemal Akdamar, Jerome Ryan, Naurang M. Agrawal, Andrew V. Schally, Akira Arimura

Houston Methodist

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Somatostatin in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography following secretin injection was determined by RIA. The mean immunoreactive somatostatin (IRS) levels in the pancreatic juice of 13 non-diabetics was 78 ± 11 (SE) pg/ml. The IRS levels in 4 non-insulin-dependent diabetics ranged from 843 to 2286 pg/ml with a mean of 1559 ± 392 (SE) pg/ml. This was significantly greater than non-diabetic values. The IRS in the pancreatic juice was immunologically indistinguishable from somatostatin ¹⁴ but consisted of 2 major components, one corresponding to somatostatin ¹⁴ and the other being of a molecular size of approximately 3000 daltons.

Original language	English (US)
Pages (from-to)	589-591
Number of pages	3
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	52
Issue number	3
DOIs	https://doi.org/10.1210/jcem-52-3-589
State	Published - Mar 1981

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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title = "Immunoreactive somatostatin in human pancreatic secretion",

abstract = "Somatostatin in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography following secretin injection was determined by RIA. The mean immunoreactive somatostatin (IRS) levels in the pancreatic juice of 13 non-diabetics was 78 ± 11 (SE) pg/ml. The IRS levels in 4 non-insulin-dependent diabetics ranged from 843 to 2286 pg/ml with a mean of 1559 ± 392 (SE) pg/ml. This was significantly greater than non-diabetic values. The IRS in the pancreatic juice was immunologically indistinguishable from somatostatin 14 but consisted of 2 major components, one corresponding to somatostatin 14 and the other being of a molecular size of approximately 3000 daltons.",

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AU - Ertan, Atilla

AU - Taminato, Tomohiko

AU - Akdamar, Kemal

AU - Ryan, Jerome

AU - Agrawal, Naurang M.

AU - Schally, Andrew V.

AU - Arimura, Akira

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AB - Somatostatin in human pancreatic juice collected during endoscopic retrograde cholangiopancreatography following secretin injection was determined by RIA. The mean immunoreactive somatostatin (IRS) levels in the pancreatic juice of 13 non-diabetics was 78 ± 11 (SE) pg/ml. The IRS levels in 4 non-insulin-dependent diabetics ranged from 843 to 2286 pg/ml with a mean of 1559 ± 392 (SE) pg/ml. This was significantly greater than non-diabetic values. The IRS in the pancreatic juice was immunologically indistinguishable from somatostatin 14 but consisted of 2 major components, one corresponding to somatostatin 14 and the other being of a molecular size of approximately 3000 daltons.

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Immunoreactive somatostatin in human pancreatic secretion

Abstract

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