TY - JOUR
T1 - Lipid-modifying activity of curcuminoids
T2 - A systematic review and meta-analysis of randomized controlled trials
AU - Simental-Mendía, Luis E.
AU - Pirro, Matteo
AU - Gotto, Antonio
AU - Banach, Maciej
AU - Atkin, Stephen L.
AU - Majeed, Muhammed
AU - Sahebkar, Amirhossein
PY - 2019/4/12
Y1 - 2019/4/12
N2 - Objective: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. Methods: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. Results: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: −21.36 mg/dL, 95% CI: −32.18, −10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: −5.82 mg/dL, 95% CI: −15.80, 4.16, p = 0.253) and total cholesterol (WMD: −9.57 mg/dL, 95% CI: −20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. Conclusion: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.
AB - Objective: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. Methods: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. Results: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: −21.36 mg/dL, 95% CI: −32.18, −10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: −5.82 mg/dL, 95% CI: −15.80, 4.16, p = 0.253) and total cholesterol (WMD: −9.57 mg/dL, 95% CI: −20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. Conclusion: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.
KW - Cardiovascular disease
KW - Cholesterol
KW - Curcumin
KW - Dyslipidemia
KW - Triglycerides
KW - Turmeric
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U2 - 10.1080/10408398.2017.1396201
DO - 10.1080/10408398.2017.1396201
M3 - Review article
C2 - 29185808
AN - SCOPUS:85066061207
SN - 1040-8398
VL - 59
SP - 1178
EP - 1187
JO - Critical Reviews in Food Science and Nutrition
JF - Critical Reviews in Food Science and Nutrition
IS - 7
ER -