@article{ef2554220a774c62acc8af8ecd55b463,
title = "Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response",
abstract = "A model of lung eosinophilia based on the repeated exposure of mice to aerosolized OVA has been used to identify C-C chemokine genes expressed at stages of massive eosinophil infiltration. We describe the identification and cloning of a cDNA that encodes a mouse C-C chemokine with 68% amino acid identity to guinea pig Eotaxin. The recombinant protein encoded by this gene displays potent and specific chemotactic activity for eosinophils, both in vivo and in vitro. Its mRNA levels parallel the kinetics of eosinophil accumulation in the lung during the experimentally induced eosinophilia and it is mainly produced by type I alveolar epithelial cells. The mRNA expression of mouse Eotaxin is not restricted to Th2 T cells in vitro and is independent of the development of a Th2-type response during N. brasiliensis infection, in vivo.",
author = "Gonzalo, {J. A.} and Jia, {G. Q.} and V. Aguirre and D. Friend and Coyle, {A. J.} and Jenkins, {N. A.} and Lin, {G. S.} and H. Katz and A. Lichtman and N. Copeland and M. Kopf and Gutierrez-Ramos, {J. C.}",
note = "Funding Information: The authors are indebted to Mr. R. Kulbacki, D. Chen, D. J. Gilbert, M. Barnstead and E. Finger for excellent technical assistance and to Drs. M. Dorf, R. Geha, and C. Gerard for critical reading of this manuscript. We especially thank Drs. T. Springer and also thank C. MacKay for his continuous support and interaction, which were integral for the complete development of this project, and Dr. C. Cepko for use of her dissecting scope and camera. Also, we are indebted to Drs. Ponath, Bozza, de la Pompa, Van Etten, Payne, Williams, and Von Andrian for technical help and important suggestions. This work has been funded in part by Leukosite, Incorporated, by National Institutes of Health grant HL 148675–02 and the Aplastic Foundation of America grants and National Cancer Institute, Department of Health and Human Services. The Basel Institute for Immunology was funded and is supported by Hoffman-La Roche, Incorporated. J.-A. G is a recipient of postdoctoral fellowship of the Spanish Ministry for Science. G-Q. J. was a recipient of a World Health Organization training grant. J-C. G-R. is the Amy C. Potter fellow. ",
year = "1996",
month = jan,
doi = "10.1016/S1074-7613(00)80293-9",
language = "English (US)",
volume = "4",
pages = "1--14",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",
}