Nanoparticle hydrophobicity dictates immune response

Daniel F. Moyano; Meir Goldsmith; David J. Solfiell; Dalit Landesman-Milo; Oscar R. Miranda; Dan Peer; Vincent M. Rotello

doi:10.1021/ja2108905

Nanoparticle hydrophobicity dictates immune response

Daniel F. Moyano, Meir Goldsmith, David J. Solfiell, Dalit Landesman-Milo, Oscar R. Miranda, Dan Peer, Vincent M. Rotello

Research output: Contribution to journal › Article › peer-review

403 Scopus citations

Abstract

Understanding the interactions of nanomaterials with the immune system is essential for the engineering of new macromolecular systems for in vivo applications. Systematic study of immune activation is challenging due to the complex structure of most macromolecular probes. We present here the use of engineered gold nanoparticles to determine the sole effect of hydrophobicity on the immune response of splenocytes. The gene expression profile of a range of cytokines (immunological reporters) was analyzed against the calculated log P of the nanoparticle headgroups, with an essentially linear increase in immune activity with the increase in hydrophobicity observed in vitro. Consistent behavior was observed with in vivo mouse models, demonstrating the importance of hydrophobicity in immune system activation.

Original language	English (US)
Pages (from-to)	3965-3967
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	134
Issue number	9
DOIs	https://doi.org/10.1021/ja2108905
State	Published - Mar 7 2012

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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title = "Nanoparticle hydrophobicity dictates immune response",

abstract = "Understanding the interactions of nanomaterials with the immune system is essential for the engineering of new macromolecular systems for in vivo applications. Systematic study of immune activation is challenging due to the complex structure of most macromolecular probes. We present here the use of engineered gold nanoparticles to determine the sole effect of hydrophobicity on the immune response of splenocytes. The gene expression profile of a range of cytokines (immunological reporters) was analyzed against the calculated log P of the nanoparticle headgroups, with an essentially linear increase in immune activity with the increase in hydrophobicity observed in vitro. Consistent behavior was observed with in vivo mouse models, demonstrating the importance of hydrophobicity in immune system activation.",

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AU - Moyano, Daniel F.

AU - Goldsmith, Meir

AU - Solfiell, David J.

AU - Landesman-Milo, Dalit

AU - Miranda, Oscar R.

AU - Peer, Dan

AU - Rotello, Vincent M.

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AB - Understanding the interactions of nanomaterials with the immune system is essential for the engineering of new macromolecular systems for in vivo applications. Systematic study of immune activation is challenging due to the complex structure of most macromolecular probes. We present here the use of engineered gold nanoparticles to determine the sole effect of hydrophobicity on the immune response of splenocytes. The gene expression profile of a range of cytokines (immunological reporters) was analyzed against the calculated log P of the nanoparticle headgroups, with an essentially linear increase in immune activity with the increase in hydrophobicity observed in vitro. Consistent behavior was observed with in vivo mouse models, demonstrating the importance of hydrophobicity in immune system activation.

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Nanoparticle hydrophobicity dictates immune response

Abstract

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