Nanotechnologies for biomolecular detection and medical diagnostics

Mark Ming Cheng Cheng; Giovanni Cuda; Yuri L. Bunimovich; Marco Gaspari; James R. Heath; Haley D. Hill; Chad A. Mirkin; A. Jasper Nijdam; Rosa Terracciano; Thomas Thundat; Mauro Ferrari

doi:10.1016/j.cbpa.2006.01.006

Nanotechnologies for biomolecular detection and medical diagnostics

Mark Ming Cheng Cheng, Giovanni Cuda, Yuri L. Bunimovich, Marco Gaspari, James R. Heath, Haley D. Hill, Chad A. Mirkin, A. Jasper Nijdam, Rosa Terracciano, Thomas Thundat, Mauro Ferrari

Research output: Contribution to journal › Review article › peer-review

436 Scopus citations

Abstract

Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.

Original language	English (US)
Pages (from-to)	11-19
Number of pages	9
Journal	Current Opinion in Chemical Biology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1016/j.cbpa.2006.01.006
State	Published - Feb 2006

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry

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10.1016/j.cbpa.2006.01.006

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title = "Nanotechnologies for biomolecular detection and medical diagnostics",

abstract = "Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.",

author = "Cheng, {Mark Ming Cheng} and Giovanni Cuda and Bunimovich, {Yuri L.} and Marco Gaspari and Heath, {James R.} and Hill, {Haley D.} and Mirkin, {Chad A.} and Nijdam, {A. Jasper} and Rosa Terracciano and Thomas Thundat and Mauro Ferrari",

note = "Funding Information: MCC, NJ and MF are grateful to the National Cancer Institute for funding under National Institute of Health Contract No. NO1-CO-12400. TT is grateful to the DOE Office of Biological and Environmental Research for financial support. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

month = feb,

doi = "10.1016/j.cbpa.2006.01.006",

language = "English (US)",

volume = "10",

pages = "11--19",

journal = "Current Opinion in Chemical Biology",

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AU - Cheng, Mark Ming Cheng

AU - Cuda, Giovanni

AU - Bunimovich, Yuri L.

AU - Gaspari, Marco

AU - Heath, James R.

AU - Hill, Haley D.

AU - Mirkin, Chad A.

AU - Nijdam, A. Jasper

AU - Terracciano, Rosa

AU - Thundat, Thomas

AU - Ferrari, Mauro

N1 - Funding Information: MCC, NJ and MF are grateful to the National Cancer Institute for funding under National Institute of Health Contract No. NO1-CO-12400. TT is grateful to the DOE Office of Biological and Environmental Research for financial support. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/2

Y1 - 2006/2

N2 - Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.

AB - Nanotechnology-based platforms for the high-throughput, multiplexed detection of proteins and nucleic acids in heretofore unattainable abundance ranges promise to bring substantial advances in molecular medicine. The emerging approaches reviewed in this article, with reference to their diagnostic potential, include nanotextured surfaces for proteomics, a two-particle sandwich assay for the biological amplification of low-concentration biomolecular signals, and silicon-based nanostructures for the transduction of molecular binding into electrical and mechanical signals, respectively.

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Nanotechnologies for biomolecular detection and medical diagnostics

Abstract

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