TY - JOUR
T1 - Nitric oxide-cyclic GMP signaling in stem cell differentiation
AU - Mujoo, Kalpana
AU - Krumenacker, Joshua S.
AU - Murad, Ferid
N1 - Funding Information:
This work was supported in part by the National Institutes of Health (GM076695) and grants from the Dunn Foundation, the Welch Foundation, the Mathers Foundation, NASA, and the University of Texas. K.M. thanks Balraj Singh and Vivek M. Singh for critically reading this review article.
PY - 2011/12/15
Y1 - 2011/12/15
N2 - The nitric oxide-cyclic GMP (NO-cGMP) pathway mediates important physiological functions associated with various integrative body systems including the cardiovascular and nervous systems. Furthermore, NO regulates cell growth, survival, apoptosis, proliferation, and differentiation at the cellular level. To understand the significance of the NO-cGMP pathway in development and differentiation, studies have been conducted both in developing embryos and in stem cells. Manipulation of the NO-cGMP pathway, by employing activators and inhibitors as pharmacological probes, and genetic manipulation of NO signaling components have implicated the involvement of this pathway in the regulation of stem cell differentiation. This review focuses on some of the work pertaining to the role of NO-cGMP in the differentiation of stem cells into cells of various lineages, particularly into myocardial cells, and in stem cell-based therapy.
AB - The nitric oxide-cyclic GMP (NO-cGMP) pathway mediates important physiological functions associated with various integrative body systems including the cardiovascular and nervous systems. Furthermore, NO regulates cell growth, survival, apoptosis, proliferation, and differentiation at the cellular level. To understand the significance of the NO-cGMP pathway in development and differentiation, studies have been conducted both in developing embryos and in stem cells. Manipulation of the NO-cGMP pathway, by employing activators and inhibitors as pharmacological probes, and genetic manipulation of NO signaling components have implicated the involvement of this pathway in the regulation of stem cell differentiation. This review focuses on some of the work pertaining to the role of NO-cGMP in the differentiation of stem cells into cells of various lineages, particularly into myocardial cells, and in stem cell-based therapy.
KW - Cyclic GMP
KW - Differentiation
KW - Free radicals
KW - Nitric oxide
KW - Stem cells
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U2 - 10.1016/j.freeradbiomed.2011.09.037
DO - 10.1016/j.freeradbiomed.2011.09.037
M3 - Review article
C2 - 22019632
AN - SCOPUS:81855167110
SN - 0891-5849
VL - 51
SP - 2150
EP - 2157
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 12
ER -