Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

Chun Luo; Neal G. Copeland; Nancy A. Jenkins; Susanne Edelhoff; Christine Disteche; Patrick G. Hogan; Anjana Rao

doi:10.1016/S0378-1119(96)00396-4

Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

Chun Luo, Neal G. Copeland, Nancy A. Jenkins, Susanne Edelhoff, Christine Disteche, Patrick G. Hogan, Anjana Rao

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.

Original language	English (US)
Pages (from-to)	29-36
Number of pages	8
Journal	Gene
Volume	180
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-1119(96)00396-4
State	Published - Nov 21 1996

Keywords

Cytokine gene expression
DNA-binding protein
Genetic diseases
RNA splicing
T cell activation
Transcription regulation

ASJC Scopus subject areas

Genetics

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10.1016/S0378-1119(96)00396-4

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title = "Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene",

abstract = "NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.",

keywords = "Cytokine gene expression, DNA-binding protein, Genetic diseases, RNA splicing, T cell activation, Transcription regulation",

author = "Chun Luo and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Susanne Edelhoff and Christine Disteche and Hogan, {Patrick G.} and Anjana Rao",

note = "Funding Information: We thank Tina M. Badalian and Debra J. Gilbert for excellent technical assistance. This research was supported, in part, by NIH grants CA42471 and GM46227 (A.R.), GM46883 (C.D.), the National Cancer Institute, DHHS, under contract with ABL (N.A.J.), grants from Hoffmann-LaRoche (A.R. and P.G.H.) and the March of Dimes (C.D.). C.L. was a recipient of a Lady Tata Memorial Trust Fellowship.",

year = "1996",

month = nov,

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doi = "10.1016/S0378-1119(96)00396-4",

language = "English (US)",

volume = "180",

pages = "29--36",

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T1 - Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

AU - Luo, Chun

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Edelhoff, Susanne

AU - Disteche, Christine

AU - Hogan, Patrick G.

AU - Rao, Anjana

N1 - Funding Information: We thank Tina M. Badalian and Debra J. Gilbert for excellent technical assistance. This research was supported, in part, by NIH grants CA42471 and GM46227 (A.R.), GM46883 (C.D.), the National Cancer Institute, DHHS, under contract with ABL (N.A.J.), grants from Hoffmann-LaRoche (A.R. and P.G.H.) and the March of Dimes (C.D.). C.L. was a recipient of a Lady Tata Memorial Trust Fellowship.

PY - 1996/11/21

Y1 - 1996/11/21

N2 - NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.

AB - NFAT1 (NFATp), a cytosolic component of the nuclear factor of activated T cells (NFAT), is encoded by a single gene which was mapped to mouse chromosome 2 in the vicinity of the wasted (wst) locus. Although wasted mice display a severe immune disorder, they express normal levels of NFAT1 protein. The NFAT1 protein in wasted mice is properly regulated and possesses comparable DNA binding activity as that in their littermate controls. Therefore, the wasted phenotype is not due to a defect in the expression or early regulation of the NFAT1 protein.

KW - Cytokine gene expression

KW - DNA-binding protein

KW - Genetic diseases

KW - RNA splicing

KW - T cell activation

KW - Transcription regulation

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AN - SCOPUS:0030597329

SN - 0378-1119

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EP - 36

JO - Gene

JF - Gene

IS - 1-2

ER -

Normal function of the transcription factor NFAT1 in wasted mice. Chromosome localization of NFAT1 gene

Abstract

Keywords

ASJC Scopus subject areas

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