Novel osteointegrative sr-substituted apatitic cements enriched with Alginate

Simone Sprio; Massimiliano Dapporto; Monica Montesi; Silvia Panseri; Wanda Lattanzi; Enrico Pola; Giandomenico Logroscino; Anna Tampieri

doi:10.3390/ma9090763

Novel osteointegrative sr-substituted apatitic cements enriched with Alginate

Simone Sprio, Massimiliano Dapporto, Monica Montesi, Silvia Panseri, Wanda Lattanzi, Enrico Pola, Giandomenico Logroscino, Anna Tampieri

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

Original language	English (US)
Article number	756
Journal	Materials
Volume	9
Issue number	9
DOIs	https://doi.org/10.3390/ma9090763
State	Published - Sep 2016

Keywords

Alginate
Bone cement
Hydroxyapatite
In vivo
Osteointegration
Strontium

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics

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10.3390/ma9090763

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abstract = "The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.",

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AU - Sprio, Simone

AU - Dapporto, Massimiliano

AU - Montesi, Monica

AU - Panseri, Silvia

AU - Lattanzi, Wanda

AU - Pola, Enrico

AU - Logroscino, Giandomenico

AU - Tampieri, Anna

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AB - The present work describes the synthesis of novel injectable, self-setting bone cements made of strontium-substituted hydroxyapatite (Sr-HA), obtained by single-phase calcium phosphate precursors doped with different amounts of strontium and enriched with alginate. The addition of alginate improved the injectability, cohesion, and compression strength of the cements, without affecting the hardening process. A Sr-HA cement exhibiting adequate hardening times and mechanical strength for clinical applications was further tested in vivo in a rabbit model, in comparison with a commercial calcium phosphate cement, revealing the maintenance of biomimetic composition and porous microstructure even after one month in vivo, as well as enhanced ability to induce new bone formation and penetration.

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Novel osteointegrative sr-substituted apatitic cements enriched with Alginate

Abstract

Keywords

ASJC Scopus subject areas

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