Protective Effect of Glucagon on the Isolated Perfused Rat Heart Following Severe Hypoxia

Ronald W. Busuttil; Richard J. Paddock; William J. George

doi:10.3181/00379727-147-38380

Protective Effect of Glucagon on the Isolated Perfused Rat Heart Following Severe Hypoxia

Ronald W. Busuttil, Richard J. Paddock, William J. George

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

It has been demonstrated that exposure of isolated perfused rat hearts to glucose-free, hypoxic medium produces a marked decline in contractile force within 3 min. Hearts which were perfused with various concentrations of glucagon during the hypoxic period recovered better during reoxygenation than hearts not perfused with glucagon. This salutary effect of glucagon was apparently unrelated to this hormone's inotropic properties since the most sustained recovery was seen when the hearts were perfused with a subinotropic dose. This evidence suggests that glucagon may exert a protective effect on the hypoxic myocardium.

Original language	English (US)
Pages (from-to)	527-532
Number of pages	6
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	147
Issue number	2
DOIs	https://doi.org/10.3181/00379727-147-38380
State	Published - Nov 1974

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Protective Effect of Glucagon on the Isolated Perfused Rat Heart Following Severe Hypoxia",

abstract = "It has been demonstrated that exposure of isolated perfused rat hearts to glucose-free, hypoxic medium produces a marked decline in contractile force within 3 min. Hearts which were perfused with various concentrations of glucagon during the hypoxic period recovered better during reoxygenation than hearts not perfused with glucagon. This salutary effect of glucagon was apparently unrelated to this hormone's inotropic properties since the most sustained recovery was seen when the hearts were perfused with a subinotropic dose. This evidence suggests that glucagon may exert a protective effect on the hypoxic myocardium.",

author = "Busuttil, {Ronald W.} and Paddock, {Richard J.} and George, {William J.}",

note = "Funding Information: Postdoctoral Surgical Research fellow supported by USPHS Grant No. GM-1559-08. 11 1974 147 2 527 532 ",

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AU - Busuttil, Ronald W.

AU - Paddock, Richard J.

AU - George, William J.

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PY - 1974/11

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N2 - It has been demonstrated that exposure of isolated perfused rat hearts to glucose-free, hypoxic medium produces a marked decline in contractile force within 3 min. Hearts which were perfused with various concentrations of glucagon during the hypoxic period recovered better during reoxygenation than hearts not perfused with glucagon. This salutary effect of glucagon was apparently unrelated to this hormone's inotropic properties since the most sustained recovery was seen when the hearts were perfused with a subinotropic dose. This evidence suggests that glucagon may exert a protective effect on the hypoxic myocardium.

AB - It has been demonstrated that exposure of isolated perfused rat hearts to glucose-free, hypoxic medium produces a marked decline in contractile force within 3 min. Hearts which were perfused with various concentrations of glucagon during the hypoxic period recovered better during reoxygenation than hearts not perfused with glucagon. This salutary effect of glucagon was apparently unrelated to this hormone's inotropic properties since the most sustained recovery was seen when the hearts were perfused with a subinotropic dose. This evidence suggests that glucagon may exert a protective effect on the hypoxic myocardium.

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Protective Effect of Glucagon on the Isolated Perfused Rat Heart Following Severe Hypoxia

Abstract

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