TY - JOUR
T1 - Real-time co-registration using novel ultrasound technology
T2 - Ex vivo validation and in vivo applications
AU - Yang, Eric Y.
AU - Polsani, Venkateshwar R.
AU - Washburn, Michael J.
AU - Zang, William
AU - Hall, Anne L.
AU - Virani, Salim S.
AU - Hodge, Megan D.
AU - Parker, Dan
AU - Kerwin, William S.
AU - Lawrie, Gerald M.
AU - Garami, Zsolt
AU - Ballantyne, Christie M.
AU - Morrisett, Joel D.
AU - Nambi, Vijay
N1 - Funding Information:
The authors thank the participants of the preliminary studies for contributions and Joanna Brooks, BA, for editorial assistance. Dr. Yang was supported by an NIH/NHLBI T32 HL007812 training grant and an American Heart Association South Central Affiliate Postdoctoral Fellowship grant at different times during this study. Dr. Nambi is supported by an NIH/NHLBI K23 HL096893 grant and received grant support from the Gulf Coast Regional Medical foundation . Clinical trial NCT00860184 is sponsored by VPDiagnostics, Inc. (Seattle WA) and supported by NIH/NHLBI R44 HL070576 .
Funding Information:
Funding: E.Y.Y. is supported by an American Heart Association South Central Affiliate Postdoctoral Fellowship grant and received support from a National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) T32 HL007812 training grant. S.S.V. is supported by a Veterans Affairs Career Development Award . V.N. is supported by an NIH/NHLBI K23 HL096893 grant and received grant support from the Gulf Coast Regional Medical Foundation .
PY - 2011/7
Y1 - 2011/7
N2 - Objective: The study objective was to evaluate whether a novel global position system (GPS)-like position-sensing technology will enable accurate co-registration of images between imaging modalities. Co-registration of images obtained by different imaging modalities will allow for comparison and fusion between imaging modalities, and therefore has significant clinical and research implications. We compared ultrasound (US) and magnetic resonance imaging (MRI) scans of carotid endarterectomy (CEA) specimens using a novel position-sensing technology that uses an electromagnetic (EM) transmitter and sensors mounted on a US transducer. We then evaluated in vivo US-US and US-MRI co-registration. Methods: Thirteen CEA specimens underwent 3.0 Tesla MRI, after which images were uploaded to a LOGIQ E9 3D (GE Healthcare, Wauwatosa, WI) US system and registered by identifying two to three common points. A similar method was used to evaluate US-MRI co-registration in patients with carotid atherosclerosis. For carotid intima-media thickness (C-IMT) measurements, 10 volunteers underwent bilateral carotid US scans co-registered to three-dimensional US maps created on the initial visit, with a repeat scan 2 days later. Results: For the CEA specimens, there was a mean of 20 (standard error [SE] 2.0) frames per MRI slice. The mean frame difference, over 33 registration markers, between MRI and US scans for readers 1 and 2 was -2.82 ± 19.32 and 2.09 ± 14.68 (mean ± 95% CI) frames, respectively. The US-MRI intraclass correlation coefficients (ICCs) for the first and second readers were 0.995 and 0.997, respectively. For patients with carotid atherosclerosis, the mean US frames per MRI slice (9 [SE 2.3]) was within range of that observed with CEA specimens. Inter-visit, intra-reader, and inter-reader reproducibility of C-IMT measurements were consistently high (side-averaged ICC >0.9). Conclusion: Accurate co-registration between US and other modalities is feasible with a GPS-like technology, which has significant clinical and research applicability.
AB - Objective: The study objective was to evaluate whether a novel global position system (GPS)-like position-sensing technology will enable accurate co-registration of images between imaging modalities. Co-registration of images obtained by different imaging modalities will allow for comparison and fusion between imaging modalities, and therefore has significant clinical and research implications. We compared ultrasound (US) and magnetic resonance imaging (MRI) scans of carotid endarterectomy (CEA) specimens using a novel position-sensing technology that uses an electromagnetic (EM) transmitter and sensors mounted on a US transducer. We then evaluated in vivo US-US and US-MRI co-registration. Methods: Thirteen CEA specimens underwent 3.0 Tesla MRI, after which images were uploaded to a LOGIQ E9 3D (GE Healthcare, Wauwatosa, WI) US system and registered by identifying two to three common points. A similar method was used to evaluate US-MRI co-registration in patients with carotid atherosclerosis. For carotid intima-media thickness (C-IMT) measurements, 10 volunteers underwent bilateral carotid US scans co-registered to three-dimensional US maps created on the initial visit, with a repeat scan 2 days later. Results: For the CEA specimens, there was a mean of 20 (standard error [SE] 2.0) frames per MRI slice. The mean frame difference, over 33 registration markers, between MRI and US scans for readers 1 and 2 was -2.82 ± 19.32 and 2.09 ± 14.68 (mean ± 95% CI) frames, respectively. The US-MRI intraclass correlation coefficients (ICCs) for the first and second readers were 0.995 and 0.997, respectively. For patients with carotid atherosclerosis, the mean US frames per MRI slice (9 [SE 2.3]) was within range of that observed with CEA specimens. Inter-visit, intra-reader, and inter-reader reproducibility of C-IMT measurements were consistently high (side-averaged ICC >0.9). Conclusion: Accurate co-registration between US and other modalities is feasible with a GPS-like technology, which has significant clinical and research applicability.
KW - Carotid plaques
KW - Co-registration
KW - Magnetic resonance imaging
KW - Plaque tissue
KW - Ultrasound
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U2 - 10.1016/j.echo.2011.02.003
DO - 10.1016/j.echo.2011.02.003
M3 - Article
C2 - 21439782
AN - SCOPUS:79959539405
SN - 0894-7317
VL - 24
SP - 720
EP - 728
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 7
ER -