TY - JOUR
T1 - Self-Assembly of Hollow Graphene Oxide Microcapsules Directed by Cavitation for Loading Hydrophobic Drugs
AU - Wei, Luyao
AU - Lu, Zhiquan
AU - Ji, Xiang
AU - Jiang, Yike
AU - Ma, Lan
N1 - Funding Information:
This work was supported by the National Key R & D Plan in China (2016YFD0501103) and the Science and Technology R & D Funds of Shenzhen, China (Grant No. GJHZ20170314164935502).
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/1/20
Y1 - 2021/1/20
N2 - Hollow graphene oxide microcapsules (GOMs) have been widely used in energy, electronics, catalysis, sensing, tissue engineering, and drug loading due to their unique properties. However, it is still a great challenge to prepare GOMs with high quality and in large quantity using a simple method. In this work, we obtained single-component GOMs using the liquid nitrogen cavitation effect, which directed the self-assembly of graphene oxide (GO) debris at the gas-liquid interface. This method avoids the introduction of additional components and removal of templates. The morphology of GOM with wrinkles on its surface was characterized by transmission electron microscopy and scanning electron microscopy. The abundant polar groups of GO microcapsules enabled them to easily disperse in water. Based on this, GOMs have good potential for loading hydrophobic drugs. Subsequently, we used GOMs as carriers to deliver a hydrophobic drug paclitaxel (PTX), which exhibited a good loading capacity. Moreover, PTX loaded GOMs showed excellent cytotoxicity to A549 and MDA-MB-231 cells. The GOMs also showed a pH-dependent drug release performance. Therefore, GOMs can be regarded as potential carriers for biomedical applications.
AB - Hollow graphene oxide microcapsules (GOMs) have been widely used in energy, electronics, catalysis, sensing, tissue engineering, and drug loading due to their unique properties. However, it is still a great challenge to prepare GOMs with high quality and in large quantity using a simple method. In this work, we obtained single-component GOMs using the liquid nitrogen cavitation effect, which directed the self-assembly of graphene oxide (GO) debris at the gas-liquid interface. This method avoids the introduction of additional components and removal of templates. The morphology of GOM with wrinkles on its surface was characterized by transmission electron microscopy and scanning electron microscopy. The abundant polar groups of GO microcapsules enabled them to easily disperse in water. Based on this, GOMs have good potential for loading hydrophobic drugs. Subsequently, we used GOMs as carriers to deliver a hydrophobic drug paclitaxel (PTX), which exhibited a good loading capacity. Moreover, PTX loaded GOMs showed excellent cytotoxicity to A549 and MDA-MB-231 cells. The GOMs also showed a pH-dependent drug release performance. Therefore, GOMs can be regarded as potential carriers for biomedical applications.
KW - cavitation
KW - graphene oxide microcapsule
KW - paclitaxel
KW - self-assembly
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U2 - 10.1021/acsami.0c16550
DO - 10.1021/acsami.0c16550
M3 - Article
C2 - 33403846
AN - SCOPUS:85099653251
SN - 1944-8244
VL - 13
SP - 2988
EP - 2996
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 2
ER -