Strategies for targeting the DNA damage respones for cancer therapeutics

Dan Zhang; Hai Bo Wang; Kathryn L. Brinkman; Su Xia Han; Bo Xu

doi:10.5732/cjc.012.10087

Strategies for targeting the DNA damage respones for cancer therapeutics

Dan Zhang, Hai Bo Wang, Kathryn L. Brinkman, Su Xia Han, Bo Xu

Academic Institute

Research output: Contribution to journal › Editorial › peer-review

6 Scopus citations

Abstract

The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

Original language	English (US)
Pages (from-to)	359-363
Number of pages	5
Journal	Chinese journal of cancer
Volume	31
Issue number	8
DOIs	https://doi.org/10.5732/cjc.012.10087
State	Published - Jun 14 2012

Keywords

DNA damage response
DNA repair
PARP inhibitors
Synthetic lethality

ASJC Scopus subject areas

Oncology

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title = "Strategies for targeting the DNA damage respones for cancer therapeutics",

abstract = "The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.",

keywords = "DNA damage response, DNA repair, PARP inhibitors, Synthetic lethality",

author = "Dan Zhang and Wang, {Hai Bo} and Brinkman, {Kathryn L.} and Han, {Su Xia} and Bo Xu",

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AU - Zhang, Dan

AU - Wang, Hai Bo

AU - Brinkman, Kathryn L.

AU - Han, Su Xia

AU - Xu, Bo

PY - 2012/6/14

Y1 - 2012/6/14

N2 - The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

AB - The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.

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KW - DNA repair

KW - PARP inhibitors

KW - Synthetic lethality

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Strategies for targeting the DNA damage respones for cancer therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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