Studies of cloning, chromosomal mapping, and embryonic expression of the mouse Rab geranylgeranyl transferase β subunit

L. N. Wei; C. H. Lee; C. Chinpaisal; N. G. Copeland; D. J. Gilbert; N. A. Jenkins; Y. C. Hsu

Studies of cloning, chromosomal mapping, and embryonic expression of the mouse Rab geranylgeranyl transferase β subunit

L. N. Wei, C. H. Lee, C. Chinpaisal, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, Y. C. Hsu

Research output: Contribution to journal › Article › peer-review

Abstract

The mouse Rab geranylgeranyl transferase β subunit has been cloned from a mouse E8.5 embryonic cDNA library. Sequence comparison reveals 97.4% sequence identity at the amino acid level to the rat clone isolated from an adult rat brain cDNA library. This gene, given a gene symbol of Rabggtb, is mapped in the distal region of mouse chromosome 3. It is ubiquitously expressed in adult animals but displays an interesting pattern of expression during a specific time of embryonic development. The expression of this gene can be detected in the whole embryos during early embryonic stages and is specifically concentrated in the developing brain, heart, and liver between gestation stages of E11.5 and E13.5. In addition, the expression of this gene is induced by retinoic acid in a mouse embryonal carcinoma cell line, P19.

Original language	English (US)
Pages (from-to)	607-614
Number of pages	8
Journal	Cell Growth and Differentiation
Volume	6
Issue number	5
State	Published - 1995

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Cite this

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abstract = "The mouse Rab geranylgeranyl transferase β subunit has been cloned from a mouse E8.5 embryonic cDNA library. Sequence comparison reveals 97.4% sequence identity at the amino acid level to the rat clone isolated from an adult rat brain cDNA library. This gene, given a gene symbol of Rabggtb, is mapped in the distal region of mouse chromosome 3. It is ubiquitously expressed in adult animals but displays an interesting pattern of expression during a specific time of embryonic development. The expression of this gene can be detected in the whole embryos during early embryonic stages and is specifically concentrated in the developing brain, heart, and liver between gestation stages of E11.5 and E13.5. In addition, the expression of this gene is induced by retinoic acid in a mouse embryonal carcinoma cell line, P19.",

author = "Wei, {L. N.} and Lee, {C. H.} and C. Chinpaisal and Copeland, {N. G.} and Gilbert, {D. J.} and Jenkins, {N. A.} and Hsu, {Y. C.}",

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pages = "607--614",

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T1 - Studies of cloning, chromosomal mapping, and embryonic expression of the mouse Rab geranylgeranyl transferase β subunit

AU - Wei, L. N.

AU - Lee, C. H.

AU - Chinpaisal, C.

AU - Copeland, N. G.

AU - Gilbert, D. J.

AU - Jenkins, N. A.

AU - Hsu, Y. C.

PY - 1995

Y1 - 1995

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Studies of cloning, chromosomal mapping, and embryonic expression of the mouse Rab geranylgeranyl transferase β subunit

Abstract

ASJC Scopus subject areas

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