@article{b3d56f4fc7b9447c994e02fe88fbbfa0,
title = "Sub-ppm level high energy resolution fluorescence detected X-ray absorption spectroscopy of selenium in articular cartilage",
abstract = "The speciation of highly-diluted elements by X-ray absorption spectroscopy in a diverse range of materials is extremely challenging, especially in biological matrices such as articular cartilage. Here we show that using a high energy resolution fluorescence detected X-ray absorption spectroscopy (HERFD-XAS) technique coupled to an array of crystal analyzers, selenium speciation down to 400 ppb (μg kg-1) within articular cartilage can be demonstrated. This is a major advance in the speciation of highly-diluted elements through X-ray absorption spectroscopy and opens new possibilities to study the metabolic role of selenium and other elements in biological samples.",
author = "C. Bissardon and O. Proux and S. Bureau and E. Suess and Winkel, {L. H.E.} and Conlan, {R. S.} and Francis, {L. W.} and Khan, {I. M.} and L. Charlet and Hazemann, {J. L.} and S. Bohic",
note = "Funding Information: We are grateful for financial contributions to the beamline development by CEMHTI (Orleans, France, ANR-13-BS080012-01) and Labex OSUG@2020 (Grenoble, France, ANR-10-LABX-0056). The FAME-UHD project is financially supported by the French “grand emprunt” EquipEx (EcoX, ANR-10-EQPX-27-01), the CEA-CNRS CRG consortium and the INSU CNRS institute. Furthermore, we thank the programme Explora{\textquoteright}doc of the Rhone-Alpes Region for financial support. The authors acknowledge the European Synchrotron Radiation Facility for provision of synchrotron radiation beamtime. E. S. and L. H. E. W. acknowledge funding by the Swiss National Science Foundation (200021_156586). IK is funded by the UK Regenerative Medicine Platform (MRL02280X/1). Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",
year = "2019",
month = jun,
day = "7",
doi = "10.1039/c9an00207c",
language = "English (US)",
volume = "144",
pages = "3488--3493",
journal = "Analyst",
issn = "0003-2654",
publisher = "Royal Society of Chemistry",
number = "11",
}