The relationship of serum androgens and ovulatory status to blood pressure in reproductive-age women

C. Ayala; E. Steinberger; A. Sweeney; W. H. Mueller; D. K. Waller; R. Hardy; S. M. Petak; L. J. Rodriguez-Rigau; K. D. Smith

doi:10.1016/S0895-7061(99)00048-5

The relationship of serum androgens and ovulatory status to blood pressure in reproductive-age women

C. Ayala, E. Steinberger, A. Sweeney, W. H. Mueller, D. K. Waller, R. Hardy, S. M. Petak, L. J. Rodriguez-Rigau, K. D. Smith

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The objective of this cross-sectional study was to determine the relationship between hyperandrogenemia and blood pressure in women with menstrual irregularities seen at an endocrinology clinic. Women with serum testosterone levels (T) ≥ 30 ng/dL were more likely to have general obesity (odds ratio [OR] = 6.8, 95% confidence intervals [CI] = 2.2-27.2) and central obesity (OR = 14.5, 95% CI = 6.1-38.7) than euandrogenemic women. Hyperandrogenemic women (HA) had an OR of 2.4 (95% CI = 1.0-6.2) for elevated SBP and an OR of 2.7 (95% CI = 0.8-8.8) for elevated DBP, independent of age and ovulatory status. Obese HA had an OR of 4.7 (95% CI = 2.3-10.4) for elevated SBP and an OR of 2.9 (95% CI = 1.9-9.9) for elevated DBP. In conclusion, T is associated with an increased risk for obesity and central adiposity. T predicts BP elevation independent of age and ovulatory status. There was a synergistic relationship between obesity and androgens in their affect on BP.

Original language	English (US)
Pages (from-to)	772-777
Number of pages	6
Journal	American Journal of Hypertension
Volume	12
Issue number	8 I
DOIs	https://doi.org/10.1016/S0895-7061(99)00048-5
State	Published - 1999

Keywords

Adiposity
Androgens
Blood pressure
Hyperandrogenemia
Hypertension

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S0895-7061(99)00048-5

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title = "The relationship of serum androgens and ovulatory status to blood pressure in reproductive-age women",

abstract = "The objective of this cross-sectional study was to determine the relationship between hyperandrogenemia and blood pressure in women with menstrual irregularities seen at an endocrinology clinic. Women with serum testosterone levels (T) ≥ 30 ng/dL were more likely to have general obesity (odds ratio [OR] = 6.8, 95% confidence intervals [CI] = 2.2-27.2) and central obesity (OR = 14.5, 95% CI = 6.1-38.7) than euandrogenemic women. Hyperandrogenemic women (HA) had an OR of 2.4 (95% CI = 1.0-6.2) for elevated SBP and an OR of 2.7 (95% CI = 0.8-8.8) for elevated DBP, independent of age and ovulatory status. Obese HA had an OR of 4.7 (95% CI = 2.3-10.4) for elevated SBP and an OR of 2.9 (95% CI = 1.9-9.9) for elevated DBP. In conclusion, T is associated with an increased risk for obesity and central adiposity. T predicts BP elevation independent of age and ovulatory status. There was a synergistic relationship between obesity and androgens in their affect on BP.",

keywords = "Adiposity, Androgens, Blood pressure, Hyperandrogenemia, Hypertension",

author = "C. Ayala and E. Steinberger and A. Sweeney and Mueller, {W. H.} and Waller, {D. K.} and R. Hardy and Petak, {S. M.} and Rodriguez-Rigau, {L. J.} and Smith, {K. D.}",

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AU - Ayala, C.

AU - Steinberger, E.

AU - Sweeney, A.

AU - Mueller, W. H.

AU - Waller, D. K.

AU - Hardy, R.

AU - Petak, S. M.

AU - Rodriguez-Rigau, L. J.

AU - Smith, K. D.

PY - 1999

Y1 - 1999

N2 - The objective of this cross-sectional study was to determine the relationship between hyperandrogenemia and blood pressure in women with menstrual irregularities seen at an endocrinology clinic. Women with serum testosterone levels (T) ≥ 30 ng/dL were more likely to have general obesity (odds ratio [OR] = 6.8, 95% confidence intervals [CI] = 2.2-27.2) and central obesity (OR = 14.5, 95% CI = 6.1-38.7) than euandrogenemic women. Hyperandrogenemic women (HA) had an OR of 2.4 (95% CI = 1.0-6.2) for elevated SBP and an OR of 2.7 (95% CI = 0.8-8.8) for elevated DBP, independent of age and ovulatory status. Obese HA had an OR of 4.7 (95% CI = 2.3-10.4) for elevated SBP and an OR of 2.9 (95% CI = 1.9-9.9) for elevated DBP. In conclusion, T is associated with an increased risk for obesity and central adiposity. T predicts BP elevation independent of age and ovulatory status. There was a synergistic relationship between obesity and androgens in their affect on BP.

AB - The objective of this cross-sectional study was to determine the relationship between hyperandrogenemia and blood pressure in women with menstrual irregularities seen at an endocrinology clinic. Women with serum testosterone levels (T) ≥ 30 ng/dL were more likely to have general obesity (odds ratio [OR] = 6.8, 95% confidence intervals [CI] = 2.2-27.2) and central obesity (OR = 14.5, 95% CI = 6.1-38.7) than euandrogenemic women. Hyperandrogenemic women (HA) had an OR of 2.4 (95% CI = 1.0-6.2) for elevated SBP and an OR of 2.7 (95% CI = 0.8-8.8) for elevated DBP, independent of age and ovulatory status. Obese HA had an OR of 4.7 (95% CI = 2.3-10.4) for elevated SBP and an OR of 2.9 (95% CI = 1.9-9.9) for elevated DBP. In conclusion, T is associated with an increased risk for obesity and central adiposity. T predicts BP elevation independent of age and ovulatory status. There was a synergistic relationship between obesity and androgens in their affect on BP.

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KW - Hypertension

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The relationship of serum androgens and ovulatory status to blood pressure in reproductive-age women

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Keywords

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