TY - JOUR
T1 - The Role of Calcium Signaling in Melanoma
AU - Zhang, Haoran
AU - Chen, Zhe
AU - Zhang, Aijun
AU - Gupte, Anisha A.
AU - Hamilton, Dale J.
N1 - Funding Information:
Funding: This research received intramural and philanthropic funding, including support from the Marvy Finger Family Foundation Distinguished Chair to D.J.H.
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.
PY - 2022/1/18
Y1 - 2022/1/18
N2 - Calcium signaling plays important roles in physiological and pathological conditions, including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium concentration ([Ca2+]i), cell membrane calcium channels, calcium related proteins (S100 family, E-cadherin, and calpain), and Wnt/Ca2+ pathways are related to melanogenesis and melanoma tumorigenesis and progression. Calcium signaling influences the melanoma microenvironment, including immune cells, extracellular matrix (ECM), the vascular network, and chemical and physical surroundings. Other ionic channels, such as sodium and potassium channels, are engaged in calcium-mediated pathways in melanoma. Calcium signaling serves as a promising pharmacological target in melanoma treatment, and its dysregulation might serve as a marker for melanoma prediction. We documented calcium-dependent endoplasmic reticulum (ER) stress and mitochondria dysfunction, by targeting calcium channels and influencing [Ca2+]i and calcium homeostasis, and attenuated drug resistance in melanoma management.
AB - Calcium signaling plays important roles in physiological and pathological conditions, including cutaneous melanoma, the most lethal type of skin cancer. Intracellular calcium concentration ([Ca2+]i), cell membrane calcium channels, calcium related proteins (S100 family, E-cadherin, and calpain), and Wnt/Ca2+ pathways are related to melanogenesis and melanoma tumorigenesis and progression. Calcium signaling influences the melanoma microenvironment, including immune cells, extracellular matrix (ECM), the vascular network, and chemical and physical surroundings. Other ionic channels, such as sodium and potassium channels, are engaged in calcium-mediated pathways in melanoma. Calcium signaling serves as a promising pharmacological target in melanoma treatment, and its dysregulation might serve as a marker for melanoma prediction. We documented calcium-dependent endoplasmic reticulum (ER) stress and mitochondria dysfunction, by targeting calcium channels and influencing [Ca2+]i and calcium homeostasis, and attenuated drug resistance in melanoma management.
KW - Calcium
KW - Melanoma
KW - Melanoma microenvironment
KW - Mitochondria
KW - Progression
KW - Humans
KW - Gene Expression Regulation, Neoplastic
KW - Tumor Microenvironment
KW - Drug Resistance, Neoplasm
KW - Melanoma/metabolism
KW - Endoplasmic Reticulum Stress
KW - Calcium Signaling
KW - Wnt Signaling Pathway
UR - http://www.scopus.com/inward/record.url?scp=85122890584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85122890584&partnerID=8YFLogxK
U2 - 10.3390/ijms23031010
DO - 10.3390/ijms23031010
M3 - Review article
C2 - 35162934
AN - SCOPUS:85122890584
SN - 1661-6596
VL - 23
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 3
M1 - 1010
ER -