The role of lncrnas in translation

Didem Karakas; Bulent Ozpolat

doi:10.3390/ncrna7010016

The role of lncrnas in translation

Didem Karakas, Bulent Ozpolat

Houston Methodist

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and posttranslational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.

Original language	English (US)
Article number	16
Pages (from-to)	1-14
Number of pages	14
Journal	Non-coding RNA
Volume	7
Issue number	1
DOIs	https://doi.org/10.3390/ncrna7010016
State	Published - Mar 2021

Keywords

Cancer
Long non-coding RNAs
NcRNAs
Non-coding RNAs
Translation

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

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10.3390/ncrna7010016

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abstract = "Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and posttranslational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.",

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The role of lncrnas in translation

Abstract

Keywords

ASJC Scopus subject areas

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