The value of pulmonary function testing in bone marrow transplantation

Introduction: The pre- and postbone marrow transplant pulmonary functions testing are widely used as standard clinical practice. However, whether there is sufficient reliable data to support and validate this practice is not confirmed. Objective: In this article we will review the publications that have assessed the role of pretransplant pulmonary functions tests for bone marrow transplant patients in identifying those patients who are at high risk for developing posttransplant noninfectious pulmonary complications. Methods: PubMed search to identify the publications that have investigated the role of pretransplant pulmonary functions tests in predicting posttransplant pulmonary complication in patients undergoing bone marrow transplant. Results: Several small studies suggest a risk of posttransplant complications associated with pretransplant obstructive patterns. Conclusion: Large randomized control trials examining pretransplant lung function are needed, including both nonmyeloablative and myeloablative conditioning regimens, to determine how pretransplant pulmonary function data can be applied clinically to reduce patient risk for significant pulmonary complications and mortality.