Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

Medicine & Life Sciences

• Spinocerebellar Ataxia 10 100%
• Microsatellite Repeats 55%
• Transgenic Mice 46%
• Seizures 40%
• Poisons 38%
• RNA 36%
• Phenotype 31%
• Heterogeneous-Nuclear Ribonucleoprotein K 17%
• 3' Untranslated Regions 16%
• Transgenes 10%
• Gait 10%
• Gain of Function Mutation 6%
• Lac Operon 6%
• Cerebellar Ataxia 6%
• Prions 6%
• Ataxia 5%
• Introns 5%
• Protein Kinase C 4%
• Cerebral Cortex 4%
• Caspase 3 4%
• Neurodegenerative Diseases 4%
• Mitochondria 4%
• Genes 4%
• Hippocampus 4%
• Apoptosis 3%
• Animals 2%
• Brain 2%