Uptake and toxicology of nanoparticles

Paul Rees

doi:10.1016/B978-0-08-098338-7.00005-4

Uptake and toxicology of nanoparticles

Paul Rees

Houston Methodist

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In both nanotoxicology and nanomedicine, the cellular uptake of particles is a crucial first step determining ensuing biological responses. This is a multifaceted process dependent upon particle dynamics under the action of diffusion and sedimentation, the influence of biological media proteins which coat the particles and the complex interactions with cell membranes and their surface molecules. This chapter reviews the current state of knowledge in this area and provides an overview of future work towards the standardisation of measurements and analysis related to nanoparticle uptake in cells.

Original language	English
Pages (from-to)	123-138
Number of pages	16
Journal	Frontiers of Nanoscience
Volume	5
DOIs	https://doi.org/10.1016/B978-0-08-098338-7.00005-4
State	Published - Sep 25 2013

Keywords

Bio-nanotechnology
Nanomedicine
Nanoparticle
Particle-cell interactions
Toxicity

ASJC Scopus subject areas

General Materials Science
Biomedical Engineering
Bioengineering

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10.1016/B978-0-08-098338-7.00005-4

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AB - In both nanotoxicology and nanomedicine, the cellular uptake of particles is a crucial first step determining ensuing biological responses. This is a multifaceted process dependent upon particle dynamics under the action of diffusion and sedimentation, the influence of biological media proteins which coat the particles and the complex interactions with cell membranes and their surface molecules. This chapter reviews the current state of knowledge in this area and provides an overview of future work towards the standardisation of measurements and analysis related to nanoparticle uptake in cells.

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KW - Nanomedicine

KW - Nanoparticle

KW - Particle-cell interactions

KW - Toxicity

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JO - Frontiers of Nanoscience

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ER -

Uptake and toxicology of nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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