Projects per year
Personal profile
Personal profile
Dr. Bulent Ozpolat earned his PhD in Immunology from the University of Texas- Houston- MD Anderson Cancer Center, Graduate School of Biomedical Sciences (GSBS), under the guidance of Lawrence Lachman. Prior to this, he obtained his M.D. degree from Dokuz Eylul University, Izmir, Turkey. His doctoral work concentrated on DNA-vaccines against HIV, Helicobacter Pylori, and HER2+ breast cancer, employing immunoliposomes with adjuvants and interleukins. Following his PhD, he underwent postdoctoral training at MD Anderson and later served 15 years as faculty in Experimental Therapeutics.
With over 135 peer-reviewed publications, he has received numerous research awards and holds patents. Supported by funding from NIH/NCI, US Congressionally Directed Medical Research & Department of Defense, Susan Komen, NHARP, CPRIT, and Blanton-Davis Ovarian Cancer Research Program, he also contributes as an editor and board member for scientific journals.
Research interests
Dr. Ozpolat's research emphasizes developing targeted cancer therapies like small molecule inhibitors and microRNA-based nanotherapeutics, using tumor-targeting nanocarriers for delivering various agents. He explores novel molecular targets, non-coding RNAs, and immune therapies for solid cancers, including breast, pancreatic, lung, ovarian, and brain tumors. Notably, his work involves nanocarriers targeting survival pathways like eEF2-kinase (eEF2K), FOXM1, KRAS, and immunosuppressive pathways like PDL1 signaling.
Education/Academic qualification
Immunology, PhD, Development of a protective vaccine against Helicobacter pylori, University of Texas at Houston Graduate School of Biomedical Sciences
Jan 14 1994 → Dec 14 1999
Award Date: Dec 14 1999
External positions
Professor of Nanomedicine in Medicine, Weill Cornell Medical College
Nov 1 2023 → …
Research Area Keywords
- Cancer
- Nanomedicine
- Precision Medicine
Free-text keywords
- Nanotechnology
- Immunology
- Cancer biology and genetics
- Drug development
- Nano-therapeutics
- targeted therapies for oncogenic pathways
- RNA therapeutics
- Gene Therapy
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Collaborations and top research areas from the last five years
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Novel Targeted Therapeutics for Breast Cancer
Ozpolat, B. (PI)
9/1/22 → 6/30/25
Project: Federal Funding Agencies
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miR-155 Targeted Therapeutics for Precision Medicine in Lung Cancer
Ozpolat, B. (PI)
8/1/22 → 7/31/24
Project: Federal Funding Agencies
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A drug repurposing study identifies novel FOXM1 inhibitors with in vitro activity against breast cancer cells
Abusharkh, K. A. N., Comert Onder, F., Çınar, V., Hamurcu, Z., Ozpolat, B. & Ay, M., Jun 25 2024, In: Medical Oncology. 41, 8, p. 188 188.Research output: Contribution to journal › Article › peer-review
Open Access -
PIM3 Kinase: A Promising Novel Target in Solid Cancers
Atalay, P. & Ozpolat, B., Jan 26 2024, In: Cancers. 16, 3, 535.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations -
SPIONs: Superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer
Kara, G. & Ozpolat, B., Feb 7 2024, In: Biomedical Microdevices. 26, 1, p. 16 16.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
The Role of Nanomedicine in Benign Gynecologic Disorders
Lulseged, B. A., Ramaiyer, M. S., Michel, R., Saad, E. E., Ozpolat, B. & Borahay, M. A., May 1 2024, In: Molecules (Basel, Switzerland). 29, 9Research output: Contribution to journal › Review article › peer-review
Open Access -
Author Correction: Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer
Rodriguez-Aguayo, C., del C Monroig, P., Redis, R. S., Bayraktar, E., Almeida, M. I., Ivan, C., Fuentes-Mattei, E., Rashed, M. H., Chavez-Reyes, A., Ozpolat, B., Mitra, R., Sood, A. K., Calin, G. A. & Lopez-Berestein, G., Nov 8 2023, In: Cell Discovery. 9, 1, p. 111 111.Research output: Contribution to journal › Article › peer-review
Open Access